Title:
純d-(17α)-13-エチル-17-ヒドロキシ-18,19-ジノルプレグ-4-エン-20-イン-3-オン-3E-及び-3Z-オキシム異性体、並びにそれらの異性体混合物及び純異性体の合成方法
Document Type and Number:
Japanese Patent JP2007534617
Kind Code:
A
Abstract:
The invention relates to the pure d-(17alpha)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yne-3-one-3E-oxime isomer of formula (IA), the pure d-(17alpha)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yne-3-one-3Z-oxime isomer of formula (IB), which are of gestagen activity, as well as the process for the synthesis of the mixture of the above isomers and the pure isomers. The invention also relates to the pharmaceutical compositions - and the process for their synthesis - which contain either the pure isomer of formula (IA) or the pure isomer of formula (IB) as active ingredient as such or in combination with other active ingredients (for example an oestrogen agent) together with pharmaceutical auxiliary materials commonly used in practice.
Inventors:
Tuba, Zoltan
Maho, sandor
Kessel, Gilger
Kozuma, Joseph
Holbass, Janos
Barrow, Gabor
Maho, sandor
Kessel, Gilger
Kozuma, Joseph
Holbass, Janos
Barrow, Gabor
Application Number:
JP2006518377A
Publication Date:
November 29, 2007
Filing Date:
April 29, 2004
Export Citation:
Assignee:
Richter Gedeon Bejeseti Jarl Earl.
International Classes:
C07J7/00; A61K31/57; A61P5/30; A61P15/18
Domestic Patent References:
| JPS624400A | 1987-01-10 | |||
| JPS624400A | 1987-01-10 |
Foreign References:
| WO1996040355A1 | 1996-12-19 | |||
| US4027019A | 1977-05-31 | |||
| WO1996040355A1 | 1996-12-19 | |||
| US4027019A | 1977-05-31 |
Other References:
JPN6010031726, ＪＡＭＡ, 2001, Ｖｏｌ．２８５， Ｎｏ．１８, ｐ．２３４７−２３５４
JPN6010031727, Ａｃｔａ Ｐｈａｒｍａｃｅｕｔｉｃａ Ｈｕｎｇａｒｉｃａ, 2003, Ｖｏｌ．７３， Ｎｏ．３, ｐ．１８５−１９５
JPN6010031727, Ａｃｔａ Ｐｈａｒｍａｃｅｕｔｉｃａ Ｈｕｎｇａｒｉｃａ, 2003, Ｖｏｌ．７３， Ｎｏ．３, ｐ．１８５−１９５
Attorney, Agent or Firm:
Haruo Hamada