Title:
PURIFICATION OF HEPARIN
Document Type and Number:
Japanese Patent JPS52108012
Kind Code:
A
Abstract:
A method for the preparation of heparin of high specific activity, characterized in that a heparin solution of a concentration of 0 to 8%, dissolved in a buffer having a ph value comprised between 5 and 9.5 and an ionic strength comprised between 0 and 0.8 m, is adsorbed on plasma proteins that fix heparin, fixed in a matrix, constituted by antithrombin iii fixed in a matrix or an inhibitor of inter.-alpha-trypsin fixed in a matrix, of a higher concentration at 0.1 mg/ml gel, and subsequently it is eluted using a buffer with a ph value between 4.5 and 10 and an ionic strength greater than 1 m. (Machine-translation by Google Translate, not legally binding)
Inventors:
RARUSUUOROFU ANDERUSON
ERITSUKU INGUBE HORUMERU
ERITSUKU INGUBE HORUMERU
Application Number:
JP2016477A
Publication Date:
September 10, 1977
Filing Date:
February 25, 1977
Export Citation:
Assignee:
KABI AB
International Classes:
A61K35/14; A61K31/715; A61K38/16; C08B37/10; G01N33/84; (IPC1-7): A61K31/725; A61K35/16