Title:
A Pyrazole - 4- Il - heterocyclyl Carboxamide compound and directions for use
Document Type and Number:
Japanese Patent JP6120861
Kind Code:
B2
Abstract:
Pyrazol-4-yl-heterocyclyl-carboxamide compounds of Formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, wherein X is thiazolyl, pyrazinyl, pyridinyl, or pyrimidinyl, are useful for inhibiting Pim kinase, and for treating disorders such as cancer mediated by Pim kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
Inventors:
Hodges, Alastair J.
Matteucci, Mizio
Sharp, andrew
Sun, Min Hoa
Tsui, Vicky H.
One, Xiao Chi
Matteucci, Mizio
Sharp, andrew
Sun, Min Hoa
Tsui, Vicky H.
One, Xiao Chi
Application Number:
JP2014531274A
Publication Date:
April 26, 2017
Filing Date:
September 26, 2012
Export Citation:
Assignee:
Ef Hoffman-La Roche Akchengezel Shaft
International Classes:
C07D401/14; A61K31/427; A61K31/438; A61K31/454; A61K31/46; A61K31/496; A61K31/5383; A61K31/55; A61K31/551; A61K31/553; A61K31/554; A61P3/00; A61P5/00; A61P9/10; A61P25/00; A61P29/00; A61P31/12; A61P35/00; A61P35/02; A61P37/02; A61P43/00; C07D403/14; C07D417/12; C07D417/14; C07D451/02; C07D471/10; C07D487/10; C07D491/107; C07D498/04; C07D498/08; C07D498/10
Domestic Patent References:
| JP2010508274A | ||||
| JP2010508278A |
Foreign References:
| WO2009014637A1 |
Attorney, Agent or Firm:
Sonoda Yoshitaka
Kobayashi Yoshinori
Kobayashi Yoshinori