PYRAZOLE COMPOUND USEFUL AS PROTEIN KINASE INHIBITOR

Japanese Patent JP2008201808

A

To provide a protein kinase inhibitor for treating diseases such as cancer, diabetes and Alzheimer's disease.

This invention describes new pyrazole compounds of formula (III). The compounds are useful as protein kinase inhibitors for treating diseases such as cancer, diabetes and Alzheimer's disease. The invention also provides a method for inhibiting Aurora-2 activity and GSK-3 activity, and a method for treating Aurora-2 mediated disease. The invention provides a method for treating colon cancer, breast cancer, stomach cancer or ovarian cancer, etc.

BEBBINGTON DAVID
CHARRIER JEAN-DAMIEN

JP2008121723A

September 04, 2008

May 07, 2008

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VERTEX PHARMACEUT INC

C07D401/14; C12N9/99; A61K31/435; A61K31/4439; A61K31/444; A61K31/4709; A61K31/4725; A61K31/496; A61K31/501; A61K31/506; A61K31/513; A61K31/517; A61K31/519; A61K31/53; A61K31/5377; A61K31/541; A61K31/55; A61K45/00; A61P1/00; A61P3/08; A61P3/10; A61P3/14; A61P5/00; A61P5/18; A61P9/00; A61P9/04; A61P9/08; A61P9/10; A61P11/06; A61P13/12; A61P15/00; A61P17/06; A61P17/14; A61P19/02; A61P19/08; A61P19/10; A61P21/00; A61P21/02; A61P21/04; A61P25/00; A61P25/02; A61P25/14; A61P25/16; A61P25/18; A61P25/28; A61P29/00; A61P31/12; A61P31/18; A61P31/20; A61P31/22; A61P35/00; A61P35/02; A61P35/04; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D401/12; C07D403/12; C07D403/14; C07D405/14; C07D407/14; C07D409/14; C07D413/14; C07D417/14; C07D471/04; C07D473/16; C07D487/04; C07D491/04; C07D493/04; C07D495/04; C07D498/04; C07D513/04; C07D521/00; A61K; A61P; C07D

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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