Title:
ピラゾール化合物、薬剤組成物、およびERABまたはHADH2活性の調節または阻害方法
Document Type and Number:
Japanese Patent JP2004506737
Kind Code:
A
Abstract:
The identification, isolation and modification of human ERAB or HADH2 is described. A crystal structure of ERAB or HADH2 is described which may be used in the discovery, identification and characterization of inhibitors or modulators of ERAB or HADH2. This structure provides a three-dimensional description of binding sites of ERAB or HADH2 for structure-based design of inhibitors or modulators thereof as therapeutic agents, for example in the treatment of Alzheimer's disease).
Inventors:
Abreo, Melwin, A.
Meng, Jerry, J.
Ugly, charles, scott
Meng, Jerry, J.
Ugly, charles, scott
Application Number:
JP2002521466A
Publication Date:
March 04, 2004
Filing Date:
August 17, 2001
Export Citation:
Assignee:
Agulon Pharmaceuticals, Inc.
International Classes:
G01N33/50; A61K31/395; A61K31/437; A61K31/4545; A61K31/496; A61K31/52; A61K31/522; A61K31/55; A61K45/00; A61P25/28; A61P35/00; A61P43/00; C07D471/04; C07D487/04; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/02; C12N15/09; C12Q1/02; G01N33/15; G06F17/50; (IPC1-7): C07D471/04; A61K31/395; A61K31/437; A61K31/4545; A61K31/496; A61K31/52; A61K31/522; A61K31/55; A61K45/00; A61P25/28; A61P35/00; A61P43/00; C07D487/04
Attorney, Agent or Firm:
Mikio Hatta
Atsushi Nogami
Yasuo Nara
Etsuko Saito
Katsuyuki Utani
Toshifumi Fujii
Atsushi Nogami
Yasuo Nara
Etsuko Saito
Katsuyuki Utani
Toshifumi Fujii