Title:
がんの処置のためのピラゾロピリジン誘導体
Document Type and Number:
Japanese Patent JP7014736
Kind Code:
B2
Abstract:
The present invention relates to a compound formula (I):and to salts thereof, wherein R1, R2 X, and Y have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.
Inventors:
Seal, Patrick
Bronner, Sara
Romero, F. Antony
Magnuson, Stephen
Tsui, Vicky Xiao-Way
Murray, Jeremy M.
Wai, John
Rye, Kwon War
One, faye
Chen, Kevin X.
Bronner, Sara
Romero, F. Antony
Magnuson, Stephen
Tsui, Vicky Xiao-Way
Murray, Jeremy M.
Wai, John
Rye, Kwon War
One, faye
Chen, Kevin X.
Application Number:
JP2018561557A
Publication Date:
February 01, 2022
Filing Date:
May 24, 2017
Export Citation:
Assignee:
Genentech, Incorporated
International Classes:
C07D471/04; A61K31/337; A61K31/437; A61K31/4725; A61K31/517; A61K33/24; A61K45/00; A61P1/04; A61P1/16; A61P1/18; A61P3/10; A61P5/14; A61P9/00; A61P9/10; A61P11/00; A61P11/08; A61P13/12; A61P17/00; A61P17/02; A61P17/04; A61P17/06; A61P19/02; A61P19/06; A61P21/00; A61P25/28; A61P27/02; A61P29/00; A61P31/04; A61P35/00; A61P35/02; A61P37/06; A61P39/02; A61P43/00; C07D519/00
Domestic Patent References:
| JP58152885A | ||||
| JP2011526283A | ||||
| JP2014526446A | ||||
| JP6771464B2 |
Other References:
Journal of Medicinal Chemstry,1985年,28(7),934-940
European Journal of Medicinal Chemistry,2014年,71,168-184
Bioorganic & Medicinal Chemistry Letters,2005年,15(6),1687-1691
DATABASE REGISTRY on STN,2015年06月28日,RN 1790625-75-0
DATABASE REGISTRY on STN,2015年06月28日,RN 1790521-98-0
DATABASE REGISTRY on STN,2015年06月28日,RN 1790521-91-3
DATABASE REGISTRY on STN,2015年06月26日,RN 1789047-56-8
DATABASE REGISTRY on STN,2012年04月13日,RN 1367868-74-3
DATABASE REGISTRY on STN,2011年12月07日,RN 1350101-01-7
DATABASE REGISTRY on STN,2011年12月05日,RN 1349159-92-7
European Journal of Medicinal Chemistry,2014年,71,168-184
Bioorganic & Medicinal Chemistry Letters,2005年,15(6),1687-1691
DATABASE REGISTRY on STN,2015年06月28日,RN 1790625-75-0
DATABASE REGISTRY on STN,2015年06月28日,RN 1790521-98-0
DATABASE REGISTRY on STN,2015年06月28日,RN 1790521-91-3
DATABASE REGISTRY on STN,2015年06月26日,RN 1789047-56-8
DATABASE REGISTRY on STN,2012年04月13日,RN 1367868-74-3
DATABASE REGISTRY on STN,2011年12月07日,RN 1350101-01-7
DATABASE REGISTRY on STN,2011年12月05日,RN 1349159-92-7
Attorney, Agent or Firm:
Shusaku Yamamoto
Morishita Natsuki
Morishita Natsuki
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