Title:
PYRIDINIUM AND QUINOLINIUM DERIVATIVES
Document Type and Number:
Japanese Patent JP2012149077
Kind Code:
A
Abstract:
To provide compounds which block the biosynthesis of phosphorylcholine by selectively blocking the choline kinase enzyme in tumor cells or in cells affected by parasitic infection and which, as a result, can be used in the treatment of tumors and parasitic diseases or diseases caused by viruses and fungi in animals including humans, and a method for producing the same.
The compounds are represented by general formula (I), wherein A represents a spacer such as benzene-1,3-diylmethylene group or biphenyl-1,3-diylmethylene group.
Inventors:
LACAL SANJUAN JUAN CARLOS
CAMPOS ROSA JOAQUIN
GALLO MEZA MIGUEL ANGEL
ESPINOSA UBEDA ANTONIO
CAMPOS ROSA JOAQUIN
GALLO MEZA MIGUEL ANGEL
ESPINOSA UBEDA ANTONIO
Application Number:
JP2012062569A
Publication Date:
August 09, 2012
Filing Date:
March 19, 2012
Export Citation:
Assignee:
CONSEJO SUPERIOR INVESTIGACION
UNIV GRANADA
UNIV GRANADA
International Classes:
C07D213/74; A61K31/14; A61K31/444; A61K31/4709; A61P31/00; A61P31/10; A61P31/12; A61P33/00; A61P33/02; A61P35/00; A61P43/00; C07D215/44
Domestic Patent References:
| JPS52105228A | 1977-09-03 |
Other References:
JPN6011011218; Ａｎａ Ｃｏｎｅｊｏ-Ｇａｒｃｉａ: 'Ｃｈｏｌｉｎｅ ｋｉｎａｓｅ ｉｎｈｉｂｉｔｏｒｙ ｅｆｆｅｃｔ ａｎｄ ａｎｔｉｐｒｏｌｉｆｅｒａｔｉｖｅ ａｃｔｉｖｉｔｙ ｏｆ ｎｅｗ １，１'，１''-（ｂｅｎｚｅｎｅ-１，３，５-ｔｒｉｙ' Ｅｕｒｏｐｅａｎ Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ ３８（１）, 2003, ｐ． １０９-１１６
JPN6011011221; Ｊｏａｑｕｉｎ Ｍ． Ｃａｍｐｏｓ: 'Ｑｕａｎｔｉｔａｔｉｖｅ Ｓｔｒｕｃｔｕｒｅ-Ａｃｔｉｖｉｔｙ Ｒｅｌａｔｉｏｎｓｈｉｐｓ ｆｏｒ ａ Ｓｅｒｉｅｓ ｏｆ Ｓｙｍｍｅｔｒｉｃａｌ Ｂｉｓｑｕａｔｅｒｎａｒｙ Ａｎｔｉｃａｎｃｅｒ Ｃ' Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ １０（７）, 2002, ｐ． ２２１５-２２３１
JPN6011011223; Ｊｏａｑｕｉｎ Ｃａｍｐｏｓ: 'Ａｎｔｉｃａｎｃｅｒ ｂｉｓｑｕａｔｅｒｎａｒｙ ｈｅｔｅｒｏｃｙｃｌｉｃ ｃｏｍｐｏｕｎｄｓ： ａ ｒａｓ-ｉｏｎａｌ ｄｅｓｉｇｎ' Ｉｌ Ｆａｒｍａｃｏ ５８（３）, 2003, ｐ． ２２１-２２９
JPN6011011226; Ｄｉｍｉｔｒｉｏｓ Ｇａｌａｎａｋｉｓ: 'Ｓｙｎｔｈｅｓｉｓ ａｎｄ Ｑｕａｎｔｉｔａｔｉｖｅ Ｓｔｒｕｃｔｕｒｅ-Ａｃｔｉｖｉｔｙ Ｒｅｌａｔｉｏｎｓｈｉｐ ｏｆ Ｄｅｑｕａｌｉｎｉｕｍ Ａｎａｌｏｇｕｅｓ ａｓ Ｋ＋ Ｃｈａｎｎｅｌ Ｂｌ' Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ ３８（１８）, 1995, ｐ． ３５３６-３５４６
JPN6011011221; Ｊｏａｑｕｉｎ Ｍ． Ｃａｍｐｏｓ: 'Ｑｕａｎｔｉｔａｔｉｖｅ Ｓｔｒｕｃｔｕｒｅ-Ａｃｔｉｖｉｔｙ Ｒｅｌａｔｉｏｎｓｈｉｐｓ ｆｏｒ ａ Ｓｅｒｉｅｓ ｏｆ Ｓｙｍｍｅｔｒｉｃａｌ Ｂｉｓｑｕａｔｅｒｎａｒｙ Ａｎｔｉｃａｎｃｅｒ Ｃ' Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ １０（７）, 2002, ｐ． ２２１５-２２３１
JPN6011011223; Ｊｏａｑｕｉｎ Ｃａｍｐｏｓ: 'Ａｎｔｉｃａｎｃｅｒ ｂｉｓｑｕａｔｅｒｎａｒｙ ｈｅｔｅｒｏｃｙｃｌｉｃ ｃｏｍｐｏｕｎｄｓ： ａ ｒａｓ-ｉｏｎａｌ ｄｅｓｉｇｎ' Ｉｌ Ｆａｒｍａｃｏ ５８（３）, 2003, ｐ． ２２１-２２９
JPN6011011226; Ｄｉｍｉｔｒｉｏｓ Ｇａｌａｎａｋｉｓ: 'Ｓｙｎｔｈｅｓｉｓ ａｎｄ Ｑｕａｎｔｉｔａｔｉｖｅ Ｓｔｒｕｃｔｕｒｅ-Ａｃｔｉｖｉｔｙ Ｒｅｌａｔｉｏｎｓｈｉｐ ｏｆ Ｄｅｑｕａｌｉｎｉｕｍ Ａｎａｌｏｇｕｅｓ ａｓ Ｋ＋ Ｃｈａｎｎｅｌ Ｂｌ' Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ ３８（１８）, 1995, ｐ． ３５３６-３５４６
Attorney, Agent or Firm:
Hirohito Katsunuma
Yukitaka Nakamura
Noritaka Yokota
Takeyasu Ito
Yukitaka Nakamura
Noritaka Yokota
Takeyasu Ito