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Title:
PYRIDOPYRIDAZINE DERIVATIVE AND ITS USE
Document Type and Number:
Japanese Patent JPH0578356
Kind Code:
A
Abstract:

PURPOSE: To provide a pyridopyridazine derivative which is a chemoluminescent substance useful for the analysis utilizing chemoluminescence.

CONSTITUTION: A compound of formula I [R1 is (substituted)hydrocarbon group or (substituted)heterocyclic group; R2 is OH, SH, amino or monosubstituted amino; when R3 is monosubstituted amino, R3 and R1 may together form a ring; R3 is H, (substituted),QH, (substituted)amino, (substituted)SH, halogen, heterocyclic group, NO2, CN, (esterified or amidated) carboxyl, azido, sulfo or organic sulfonyl; R3 is not H when R1 is aliphatic group; X is 0 or S] or its salt, e.g. 8-hydroxy-7-(p-methoxyphenyl) pyrido[3,4-d]pyridazine-1,4(2H,3H) dione. The compounds of formula are new except for those wherein R3 is H and R1 is (substituted)aralkyl or unsubstituted aryl. For example, a compound of formula II (R is lower alkyl) is made to react with hydrazine to obtain the corresponding compound of formula I wherein X is O.


Inventors:
Masuya, Hironaga
Aramaki, Yoshio
Kondo, Koichi
Application Number:
JP1991000312347
Publication Date:
March 30, 1993
Filing Date:
November 27, 1991
Export Citation:
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Assignee:
TAKEDA CHEM IND LTD
International Classes:
C07D471/04; C07D471/14; C07D491/048; G01N33/532; (IPC1-7): C07D471/04; C07D471/14; C07D491/048; G01N33/532
Attorney, Agent or Firm:
青山 葆 (外1名)