Title:
【発明の名称】ピリミジン化合物
Document Type and Number:
Japanese Patent JP2002523497
Kind Code:
A
Abstract:
A pyrimidine derivative of formula (I) wherein, for example, R1 is hydrogen, (1-6C)alkyl, (3-5C)alkenyl or (3-5C)alkynyl; Q1 and Q2 are independently selected from phenyl, naphthyl, indanyl and 1,2,3,4-tetrahydronaphthyl; and one or both of Q1 and Q2 bears on any available carbon atom one substituent of formula (Ia) [provided that when present in Q1 the substituent of formula (Ia) is not adjacent to the -NH- link]; wherein, for example, X is CH2, O, S or NH; Y is H or as defined for Z; Z is OH, SH, NH2, (1-4C)alkoxy, (1-4C)alkylthio, -NH(1-4C)alkyl, -N[(1-4C)alkyl]2 or -NH-(3-8C)cycloalkyl; n is 1, 2 or 3; m is 1, 2 or 3; and Q1 and Q2 may optionally bear other substituents selected, for example, from halogeno, (1-6C)alkyl, cyano and (2-4C)alkenyl; or a pharmaceutically-acceptable salt or in-vivo-hydrolysable ester thereof; are useful as anti-cancer agents; and processes for heir manufacture and pharmaceutical compositions containing them are described.
Inventors:
Gloria an broult
Janet Elizabeth Peas
Janet Elizabeth Peas
Application Number:
JP2000567515A
Publication Date:
July 30, 2002
Filing Date:
August 24, 1999
Export Citation:
Assignee:
ASTRAZENECA AKTIEBOLAG
International Classes:
C07D239/49; A61K31/505; A61K31/506; A61K31/5355; A61P9/00; A61P9/10; A61P13/12; A61P17/06; A61P19/00; A61P27/02; A61P29/00; A61P35/00; A61P37/00; A61P43/00; C07D239/48; C07D403/12; (IPC1-7): C07D239/49; A61K31/505; A61K31/506; A61K31/5355; A61P9/00; A61P9/10; A61P13/12; A61P17/06; A61P19/00; A61P27/02; A61P29/00; A61P35/00; A61P37/00; A61P43/00; C07D403/12
Foreign References:
| WO1997019065A1 | 1997-05-29 |
Attorney, Agent or Firm:
Chika Takagi (2 outside)