Title:
【発明の名称】ピリミジン化合物
Document Type and Number:
Japanese Patent JP2003525276
Kind Code:
A
Abstract:
Pyrimidine derivatives of the formula (I) wherein: one of Q1 and Q2 or both of Q1 and Q2 is substituted on a ring carbon by one substituent of the formula (Ia) [provided that when present in Q1 the substituent of formula (Ia) is not adjacent to the -NH- link]; wherein Q1, Q2, G, R<1>, X, Y<1>, Y<2>, Z, n and m are as described within; and pharmaceutically acceptable salts and in vivo hydrolyzable esters thereof are described. Processes for their manufacture, pharmaceutical compositions and their use as cyclin-dependent serine/threonine kinase (CDK) and focal adhesion kinase (FAK) inhibitors are also described.
Inventors:
Peace, Elizabeth Janet
Bleort, Gloria Ann
Bradbury, Robert Hugh
Bleort, Gloria Ann
Bradbury, Robert Hugh
Application Number:
JP2001563495A
Publication Date:
August 26, 2003
Filing Date:
February 26, 2001
Export Citation:
Assignee:
AstraZeneca Activrag
International Classes:
A61K31/505; A61K31/506; A61K31/513; A61P9/00; A61P9/10; A61P13/12; A61P17/06; A61P19/08; A61P27/02; A61P29/00; A61P35/00; A61P35/02; A61P37/06; A61P43/00; C07D239/46; C07D417/12; C07D239/47; (IPC1-7): C07D239/47; A61K31/505; A61K31/506; A61K31/513; A61P9/00; A61P9/10; A61P13/12; A61P17/06; A61P19/08; A61P27/02; A61P29/00; A61P35/00; A61P35/02; A61P37/06; A61P43/00; C07D417/12
Domestic Patent References:
| JP2005041878A | 2005-02-17 |
Foreign References:
| WO1998041512A1 | 1998-09-24 | |||
| WO1997019065A1 | 1997-05-29 |
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)