Title:
グルタミン酸受容体としてのピリミジン、トリアジン及びピラジン誘導体
Document Type and Number:
Japanese Patent JP4049742
Kind Code:
B2
Abstract:
The present invention is a pyrimidine, triazine or pyrazine derivative of the formula or a pharmaceutically acceptable salt thereof wherein R1, R2, R3, R4, X, Y and Z are as defined in the specification. The invention is a pharmaceutical composition containing an effective amount of the compound of formula 1, its preparation and to a method of treatment, control or prevention of acute and/or chronic neurological disorders by administering a therapeutically effective amount of a compound of formula 1.
Inventors:
Bingeri, Alfred
Melchi, Hans-Peter
Muscarin, Thierry
Muntel, Vincent
Willem, Maurice
Vostel, Wolfgang
Melchi, Hans-Peter
Muscarin, Thierry
Muntel, Vincent
Willem, Maurice
Vostel, Wolfgang
Application Number:
JP2003501988A
Publication Date:
February 20, 2008
Filing Date:
May 27, 2002
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07D239/46; C07D253/06; A61K31/497; A61K31/4995; A61K31/506; A61K31/513; A61K31/53; A61P1/08; A61P7/12; A61P9/00; A61P9/02; A61P9/10; A61P25/00; A61P25/04; A61P25/06; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P25/34; A61P25/36; A61P27/02; A61P43/00; C07D239/47; C07D239/48; C07D239/50; C07D241/26; C07D253/075; C07D401/04; C07D401/12; C07D401/14
Domestic Patent References:
| JP2001089472A | ||||
| JP11509839A | ||||
| JP11228568A |
Foreign References:
| WO1999019305A1 | ||||
| WO2001062233A1 |
Attorney, Agent or Firm:
Hajime Tsukuni
Fumio Shinoda
Fumio Shinoda