PYROGLUTAMATE SALT AND USE OF THE SAME IN OPTICAL RESOLUTION OF INTERMEDIATE FOR SYNTHESIS OF DEXTROCETIRIZINE AND LEVOCETIRIZINE

Title:

PYROGLUTAMATE SALT AND USE OF THE SAME IN OPTICAL RESOLUTION OF INTERMEDIATE FOR SYNTHESIS OF DEXTROCETIRIZINE AND LEVOCETIRIZINE

Document Type and Number:

Japanese Patent JP2013032380

Kind Code:

A

Abstract:

To provide a simpler preparation method for an enantiomerically and essentially pure compound like levocetirizine or the like by using a novel and enantiomerically and essentially pure intermediate.

There is provided a (S)-2-[4-(4-chlorobenzhydryl)piperazine-1-yl]-ethoxyacetamide-(S)-pyrrolidone-5-carboxylic acid salt, (R)-2-[4-(4-chlorobenzhydryl)piperazine-1-yl]-ethoxyacetamide-(S)-pyrrolidone-5-carboxylic acid salt, (S)-2-[4-(4-chlorobenzhydryl)piperazine-1-yl]-ethoxyacetamide-(R)-pyrrolidone-5-carboxylic acid salt, or (R)-2-[4-(4-chlorobenzhydryl)piperazine-1-yl]-ethoxyacetamide-(R)-pyrrolidone-5-carboxylic acid salt. There is also provided the preparation method for (S)-2-[4-(4-chlorobenzhydryl)piperazine-1-yl]-ethoxyacetamide (I) and (R)-2-[4-(4-chlorobenzhydryl)piperazine-1-yl]-ethoxyacetamide (II) by chemical resolution of a mixture.

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Inventors:

PALACIO MAGALI
ATES CELAL

Application Number:

JP2012226914A

Publication Date:

February 14, 2013

Filing Date:

October 12, 2012

Export Citation:

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Assignee:

UCB FARCHIM SA

International Classes:

C07D295/08; C07B57/00; C07D207/28

Attorney, Agent or Firm:

Hideto Asamura
Hajime Asamura
Yukihiro Ikeda
Naganuma Akio

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