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Title:
PYRROLOPYRIDINE COMPOUND USEFUL AS INHIBITOR FOR PROTEIN KINASE
Document Type and Number:
Japanese Patent JP2009179644
Kind Code:
A
Abstract:

To provide a compound useful as a protein kinase inhibitor.

Provided is a composition comprising the compound, or a composition comprising a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable vehicle thereof, an adjuvant, or a solvent. The amount of compound in the composition is an effective amount to inhibit the protein kinases originating from a biological sample or a sample from a patient, in particular the JAK family or ROCK family kinases to a measurable degree. Preferably the composition is prepared for administration to a patient in need of the composition. The composition is prepared for oral administration to the patient in need of the composition.


Inventors:
LEDEBOER MARK W
WANNAMAKER MARION W
FARMER LUC J
WANG TIANSHENG
PIERCE ALBERT C
MARTINEZ-BOTELLA GABRIEL
BETHIEL RANDY S
BEMIS GUY W
WANG JIAN
SALITURO FRANCESCO G
ARNOST MICHAEL J
COME JON H
GREEN JEREMY
STEWART MICHELLE
MARHEFKA CRAIG
Application Number:
JP2009123635A
Publication Date:
August 13, 2009
Filing Date:
May 21, 2009
Export Citation:
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Assignee:
VERTEX PHARMACEUT INC
International Classes:
C07D471/04; A61K31/437; A61K31/444; A61K31/4725; A61K31/496; A61K31/506; A61K31/517; A61K31/519; A61K31/5415; A61K31/551; A61P35/00; A61P35/02; A61P43/00; C07D519/00
Domestic Patent References:
JP2004534826A2004-11-18
JP2003503481A2003-01-28
JP2004501152A2004-01-15
JP2008525453A2008-07-17
JP2008516973A2008-05-22
JP2007536280A2007-12-13
JP2007534710A2007-11-29
JP2008525463A2008-07-17
JP2008540664A2008-11-20
JP2008528679A2008-07-31
JP2009523812A2009-06-25
JP2008517983A2008-05-29
JP2008512380A2008-04-24
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JP2007512364A2007-05-17
JP2008517984A2008-05-29
Foreign References:
WO2006052568A22006-05-18
WO2001081345A12001-11-01
WO2004085425A12004-10-07
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Other References:
JPN5008006241; THUTEWOHL,MICHAEL: SYNTHESIS N4, 2006, P629-632
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita