Title:
ＴＬＲ７アゴニストとして使用されるピロロピリミジン化合物
Document Type and Number:
Japanese Patent JP6639551
Kind Code:
B2
Abstract:
The present invention relates to a pyrrolopyrimidine compound as TLR7 agonist, and particularly relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, a preparation process thereof, a pharmaceutical composition containing such compounds and use thereof for manufacturing a medicament against viral infection.
Inventors:
Din, Zao Tson
U hao
Sun, faye
C, Rifan
Yang, Lin
U hao
Sun, faye
C, Rifan
Yang, Lin
Application Number:
JP2018079330A
Publication Date:
February 05, 2020
Filing Date:
April 17, 2018
Export Citation:
Assignee:
Chia Tai Tianqing Pharmaceutical Group Co.,Ltd.
International Classes:
C07D487/04; A61K31/519; A61K31/5377; A61K31/551; A61P31/12
Domestic Patent References:
| JP2014504644A | ||||
| JP2009504803A | ||||
| JP6328341B2 |
Foreign References:
| WO2014081644A1 | ||||
| WO2014081643A1 | ||||
| WO2014081645A1 | ||||
| WO2014056953A1 |
Other References:
OTMAR,M. et al,Synthesis and antiproliferative activity of 2,6-diamino-9-benzyl-9-deazapurine and related compounds,Bioorganic & Medicinal Chemistry,2004年 5月10日,Vol.12, No.12,p.3187-3195
Paul A. Roethle et al,Identification and Optimization of Pteridinone Toll-like Receptor 7(TLR7) Agonists for the Oral Trea,J. MED. CHEM.,2013年 8月20日,vol.56, no.18,p.7324-7333
Paul A. Roethle et al,Identification and Optimization of Pteridinone Toll-like Receptor 7(TLR7) Agonists for the Oral Trea,J. MED. CHEM.,2013年 8月20日,vol.56, no.18,p.7324-7333
Attorney, Agent or Firm:
Ikeda adult
Junichiro Sakamaki
Masakazu Noda
Junichiro Sakamaki
Masakazu Noda