Quantification of the tomoxifen by mass spectrometry, and its metabolic product

Title:

Quantification of the tomoxifen by mass spectrometry, and its metabolic product

Document Type and Number:

Japanese Patent JP6279104

Kind Code:

B2

Abstract:

Provided are methods for determining the amount of tamoxifen and its metabolites in a sample by mass spectrometry. In some aspects, the methods provided herein comprise determining the amount of norendoxifen. In some aspects, the methods provided herein comprise determining the amount of norendoxifen and tamoxifen. In some aspects, the methods provided herein comprise determining the amount of norendoxifen and other tamoxifen metabolites. In some aspects, the methods provided herein comprise determining the amount of tamoxifen, norendoxifen, and other tamoxifen metabolites.

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Inventors:

Clark, Niger

Application Number:

JP2016567654A

Publication Date:

February 14, 2018

Filing Date:

May 12, 2015

Export Citation:

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Assignee:

Quest Diagnostics Investments Inc.

International Classes:

G01N27/62

Foreign References:

WO2014014279A1

Other References:

Wei Lv,Synthesis of Mixed (E,Z)-, (E)-, and (Z)-Norendoxifen with Dual Aromatase Inhibitory and Estrogen Receptor Modulatory Activities,Journal of Medical Chemistry,米国,American Chemical Society,2013年 6月 3日,Vol.56/Iss.11,PP.4611-4618

Attorney, Agent or Firm:

Seiji Ohno
Reiko Tanaka
Yuko Matsuniya
Ken Kitano
Umeda Shinsuke
Hiroshi Morita

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