Title:
キナゾリン化合物
Document Type and Number:
Japanese Patent JP2005522428
Kind Code:
A
Abstract:
The invention relates to compounds of the formula I:
wherein ring C is as defined herein, for example indolyl, indazolyl or azaindolyl; Z is -O-, -NH- or -S-; n is 0-5; m is 0-3; R 1 and R 2 are defined herein including groups:
(i) Q 1 X 1 wherein Q 1 and X 1 are as defined herein;
(ii) Q15W 3 wherein Q 15 and W 3 are as defined herein,
(iii) Q 21 W 4 C 1-5 alkylX 1 - wherein Q 21 , W 4 and X 1 are as defined herein,
(iv) Q 28 C 1-5 alkylX 1 -, Q 28 C 2-5 alkenylX 1- or Q 28 C 2-5 alkynylX 1 - wherein Q 28 and X 1 are as defined herein and
(v) Q 29 C 1-5 alkylX 1 -, Q 29 C 2-5 alkenylX 1 - or Q 29 C 2-5 alkynylx 1 - wherein Q 29 and X 1 are as defined herein; R 2 can also be 6,7-methylenedioxy or 6,7-ethylenedioxy;
and salts thereof; their use in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals; processes for the preparation of such compounds; intermediates used in such processes; processes for making such intermediates; pharmaceutical compositions containing a compound of formula I or a pharmaceutically acceptable salt thereof and methods of treating disease states involving angiogenesis by administering a compound of formula I or a pharmaceutically acceptable salt thereof. The compounds of formula I inhibit the effects of VEGF, a property of value in the treatment of a number of disease states including cancer and rheumatoid arthritis.
Inventors:
Hennekin, Laurent Francois Andre
Application Number:
JP2003564036A
Publication Date:
July 28, 2005
Filing Date:
January 28, 2003
Export Citation:
Assignee:
AstraZeneca Activrag
International Classes:
A61K31/517; A61K31/519; A61P9/00; A61P35/00; C07D401/14; C07D403/12; C07D403/14; C07D471/04; C07D491/04; C07D491/113; C07D519/00; (IPC1-7): C07D403/12; A61K31/517; A61K31/519; A61P9/00; C07D401/14; C07D403/14; C07D471/04; C07D491/113; C07D519/00
Domestic Patent References:
| JP2004506732A | 2004-03-04 |
Foreign References:
| WO1999035132A1 | 1999-07-15 | |||
| WO1997003069A1 | 1997-01-30 | |||
| WO2001094341A1 | 2001-12-13 | |||
| WO2000047212A1 | 2000-08-17 | |||
| WO2001074360A1 | 2001-10-11 | |||
| WO1996039145A1 | 1996-12-12 | |||
| WO1995015758A1 | 1995-06-15 | |||
| EP0602851A1 | 1994-06-22 | |||
| EP0837063A1 | 1998-04-22 |
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Keiko Kanemoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Keiko Kanemoto