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Title:
QUINAZOLINE COMPOUND
Document Type and Number:
Japanese Patent JP2010100642
Kind Code:
A
Abstract:

To provide a compound or a salt thereof effective for the treatment of disease states involving angiogenesis and/or increased vascular permeability, which is an effective ingredient of medicines used for providing an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals such as human beings.

The compound comprises 7-benzyloxy-4-(4-fluoro-2-methylindol-5-yloxy)-6-methoxyquinazoline or a salt thereof, and 4-(4-fluoro-2-methylindol-5-yloxy)-7-hydroxy-6-methoxyquinazoline or a salt thereof. The administration of the compound or a pharmaceutically acceptable salt thereof can treat disease states involving angiogenesis. The compound inhibits the action of the vascular endothelial cell growth factor (VEGF), which is a characteristic useful for the treatment of several disease states including cancer and rheumatoid arthritis.


Inventors:
HENNEQUIN LAURENT FRANCOIS A
Application Number:
JP2009297126A
Publication Date:
May 06, 2010
Filing Date:
December 28, 2009
Export Citation:
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Assignee:
ASTRAZENECA AB
International Classes:
C07D403/12; A61K31/517; C07D491/113; A61K31/519; A61P9/00; A61P35/00; C07D401/14; C07D403/14; C07D471/04; C07D491/04; C07D519/00; A61P3/10; A61P7/02; A61P9/08; A61P9/10; A61P9/14; A61P13/12; A61P15/00; A61P17/02; A61P17/06; A61P19/02; A61P27/02; A61P29/00; A61P35/02; A61P37/06; A61P43/00
Foreign References:
WO2000047212A12000-08-17
WO2001074360A12001-10-11
Attorney, Agent or Firm:
Shinjiro Ono
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Akiko Nakahama



 
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