Title:
ポリ(ADP-リボース)ポリメラーゼ(PARP)阻害剤としてのキノリン-4-オン及び4-オキソジヒドロシンノリン誘導体
Document Type and Number:
Japanese Patent JP2010536842
Kind Code:
A
Abstract:
The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal damage, skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment.
Inventors:
Philip, Jones
Kinzel, Olaf
Koch, you
Ontoria Ontoria, Jesus Maria
Pescatore, Giovanna
Scarpelli, Rita
Trissi, Katerina
Kinzel, Olaf
Koch, you
Ontoria Ontoria, Jesus Maria
Pescatore, Giovanna
Scarpelli, Rita
Trissi, Katerina
Application Number:
JP2010521488A
Publication Date:
December 02, 2010
Filing Date:
August 21, 2008
Export Citation:
Assignee:
ESTACH YOUT DAY LICHIERQUE DAY VIOLOSIA MORE CORRALE PI ANGE ELETS ESET PEAR
International Classes:
C07D215/22; A61K31/4709; A61K31/496; A61K31/4985; A61K31/502; A61K31/551; A61P3/10; A61P9/00; A61P9/10; A61P13/12; A61P17/00; A61P17/16; A61P25/00; A61P27/02; A61P29/00; A61P31/12; A61P35/00; A61P43/00; C07D237/26; C07D401/12; C07D403/10; C07D471/04; C07D471/10; C07D487/04; C07D487/08; C07D487/10; C07D498/04
Domestic Patent References:
| JPH04360872A | 1992-12-14 | |||
| JP2006519827A | 2006-08-31 |
Foreign References:
| WO2006021801A1 | 2006-03-02 | |||
| WO2007059108A2 | 2007-05-24 | |||
| WO1997005114A1 | 1997-02-13 |
Attorney, Agent or Firm:
Yokoyama Isao
Previous Patent: 増殖性疾患治療のためのＴＴＫ／ＭＰＳ１阻害剤としての２−アニリノプ...
Next Patent: 有機リン酸エステル暴露関連損傷を処置または防止するための物質および...
Next Patent: 有機リン酸エステル暴露関連損傷を処置または防止するための物質および...