Title:
サーチュイン調節薬としてのキノリンおよび関連する類似体
Document Type and Number:
Japanese Patent JP5425891
Kind Code:
B2
Abstract:
Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
Inventors:
Ji Bee
Jeremy, S. Dish
Stephanie, Kay Springer
Charles A. Bram
Robert, B. Perni
Jeremy, S. Dish
Stephanie, Kay Springer
Charles A. Bram
Robert, B. Perni
Application Number:
JP2011507632A
Publication Date:
February 26, 2014
Filing Date:
April 30, 2009
Export Citation:
Assignee:
Sir Tris Pharmaceuticals, Inc.
International Classes:
C07D215/40; A61K31/47; A61K31/4706; A61K31/4709; A61K31/496; A61K31/497; A61K31/498; A61K31/501; A61K31/506; A61K31/517; A61K31/519; A61K31/5377; A61K45/00; A61P3/00; A61P3/10; A61P5/50; C07D215/48; C07D401/12; C07D401/14; C07D405/12; C07D405/14; C07D413/12; C07D413/14; C07D417/12; C07D417/14; C07D453/02; C07D471/04; A61P1/16; A61P3/04; A61P3/06; A61P7/02; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P11/00; A61P13/12; A61P15/08; A61P17/00; A61P19/02; A61P19/06; A61P19/10; A61P21/00; A61P25/00; A61P25/28; A61P27/02; A61P29/00; A61P35/00; A61P43/00
Domestic Patent References:
| JP62048669A | ||||
| JP2004043457A | ||||
| JP2002363169A |
Foreign References:
| US20080021063 | ||||
| WO2006069805A2 | ||||
| WO2006135993A1 | ||||
| WO2006094237A2 | ||||
| WO2006094236A1 |
Other References:
Chemistry of Heterocyclic Compounds,2002年,38(8),908-912
Attorney, Agent or Firm:
Hirohito Katsunuma
Yukitaka Nakamura
Noritaka Yokota
Takeyasu Ito
Yukitaka Nakamura
Noritaka Yokota
Takeyasu Ito