Title:
QUINOLINE DERIVATIVE AND ITS PREPARATION
Document Type and Number:
Japanese Patent JPS55100365
Kind Code:
A
Abstract:
NEW MATERIAL:A quinoline derivative of formula I (R1 is vinyl, ethyl, 2-fluoro- ethyl,2,2,2-trifluoroethyl or methoxy) or its pharmacologically permissible salt.
EXAMPLE: 6-Fluoro-7-methyl-1-vinyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid.
USE: Antibacterial agent effective to gram-positive and gram-negative bacteria, and having wide safety range and broad antibacterial spectrum.
PROCESS: A quinoline derivative IV can be prepared by reacting, e.g. a quinoline derivative II (R2 is ester residue) with an alkylating agent III (R3 is ethyl, 2-fluoroethyl, or 2,2,2-trifluoroethyl; X1 is Cl, Br, or I), and an objective compound I-a is prepared by hydrolyzing the compound IV.
Inventors:
MUSHISHIKA YOSHITAKA
TANI JIYUNICHI
YAMAGUCHI TOUTAROU
OOSHIMA SATOSHI
TANI JIYUNICHI
YAMAGUCHI TOUTAROU
OOSHIMA SATOSHI
Application Number:
JP838679A
Publication Date:
July 31, 1980
Filing Date:
January 26, 1979
Export Citation:
Assignee:
TANABE SEIYAKU CO
International Classes:
C07D215/56; A61K31/47; A61P31/04; (IPC1-7): A61K31/47; C07D215/56