【発明の名称】キノン誘導体

Japanese Patent JP2919030

B2

The quinone compound is useful to treat hepatic disease and defined by the formula: wherein A is a group represented by the formula: (wherein R<3>, R<4> and R<5> which may be the same or different from each other are each a hydrogen atom, a lower alkyl group or a lower alkoxy group) or a group represented by the formula: (wherein R<3>, R<4> and R<5> which may be the same or different from each other are each a hydrogen atom, a lower alkyl group or a lower alkoxy group, X and Y which may be the same or different from each other are each a hydroxyl group, a group represented by the formula &lparstr& OCH2 &rparstr& @ OR<6> (wherein n is 0 or 1 and R<6> is a lower alkyl group), or an acyl group), R<1> is an alkyl group having 2 to 20 carbon atoms, a cycloalkyl group, a cycloalkylalkyl group, an alkenyl group, an alkynyl group, an arylalkyl group, a group represented by the formula &lparstr& CH2 &rparstr& @ CN (wherein p is an integer of 1 to 10), a heteroarylalkyl group, a group represented by the formula &lparstr& CH2 &rparstr& @ B {wherein q is an integer of 1 to 6 and B is a group represented by the formula: (wherein r is 0 or an integer of 1 to 2, R<7> is a lower alkyl group, a cycloalkyl group or an aryl group), or a group represented by the formula -O-R<8> (wherein R<8> is a lower alkyl group or an aryl group)}, or a group represented by the formula &lparstr& CH2-CH2-O)@ CH3 (wherein s is an integer of 1 to 3), R<2> is a group represented by the formula -OR<8> (wherein R<8> is a hydrogen atom or a lower alkyl group) or a group represented by the formula: (wherein R<9> and R<1><0> which may be the same of different from each other are each a hydrogen atom, a lower alkyl group, a hydroxyalkyl group or a heteroaryl group, provided that R<9> and R<1><0> may be combined with each other to form a ring together with a nitrogen atom bonded thereto, which may further contain a nitrogen atom and/or an oxygen atom and may be substituted).

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ABE SHINYA
OKAMOTO YASUSHI
TAGAMI KATSUYA
HIBI SHIGEKI
NAGAGAWA JUNICHI
HIROTA KAZUO
HISHINUMA TAKAHARU
MYAMOTO KANAME
YAMANAKA TEIJI
YOKOHAMA HIROMITSU
YOSHIMURA TSUTOMU
HORIE TOORU
AKITA MASANORI KA

JP23705190A

July 12, 1999

September 10, 1990

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EEZAI KK

A61K31/00; A61K31/19; A61K31/215; A61K31/255; A61K31/275; A61K31/35; A61K31/351; A61K31/38; A61K31/381; A61K31/425; A61K31/426; A61K31/44; A61K31/4406; A61K31/4409; A61K31/4418; A61K31/445; A61K31/495; A61K31/535; A61K31/5375; A61P1/00; A61P1/16; C07C45/00; C07C47/575; C07C50/38; C07C51/09; C07C59/54; C07C59/58; C07C59/64; C07C59/68; C07C59/72; C07C59/82; C07C59/90; C07C65/21; A61K31/16; C07C66/00; C07C69/16; C07C69/734; C07C69/738; C07C235/30; C07C235/78; C07C255/31; C07C255/41; C07C255/53; C07C255/57; C07C317/24; C07C317/44; C07C317/46; C07C323/55; C07C323/56; C07C323/60; C07C323/62; C07D211/46; C07D213/55; C07D265/30; C07D277/20; C07D277/22; C07D277/24; C07D277/30; C07D277/46; C07D295/18; C07D295/185; C07D309/04; C07D309/06; C07D333/24; C07D521/00; (IPC1-7): C07C59/64; A61K31/00; A61K31/16; A61K31/19; A61K31/215; A61K31/255; A61K31/275; A61K31/35; A61K31/38; A61K31/425; A61K31/44; A61K31/445; A61K31/495; A61K31/535; C07C59/72; C07C66/00; C07C69/16; C07C69/734; C07C235/30; C07C235/78; C07C255/31; C07C255/41; C07C255/57; C07C317/44; C07C317/46; C07C323/56; C07C323/60; C07D211/46; C07D213/55; C07D277/24; C07D277/46; C07D295/18; C07D309/06

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