Title:
Quinoxalines and Bruises - quinoxalines as a CRTH2 receptor-regulation agent
Document Type and Number:
Japanese Patent JP5952829
Kind Code:
B2
Abstract:
The invention provides certain quinoxalines and aza-quinoxalines of the Formula (I), and their pharmaceutically acceptable salts, wherein J1, J2, R1, R2, R3, R22, Ra, Rb, Rc, Rd, X, Y, b, n, and q are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions associated with uncontrolled or inappropriate stimulation of CRTH2 function.
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Inventors:
Voice, Christopher D'Abrieu
Degrad, Sylvia Giouanna
Chiao, Xiao
Chin, Ji Yuin
Matsuzora, Robert Day, Giunia
Yui, Yong Noon
McCormick, Kevin Day
Paranai, Anandang
Xiao, Dawn
Aslanian, Robert Giyogi
Woo, Jie
Lao, Ashwin Umetsushiyu
Sirih Ivan, Huyen
Method, Joey Lee
The Yarn, Horn The Yuin
Kelly, Elizabeth Helen
Brown, William Colby
Jean, Chin
Gooan, Giorricia Polyvina
Ray Hein, Andrew Jei
Bijyu, Pratsk Quatre Jeanny
Dawn Day, Pawan Kay
Don Lee
Huber, Salem
Huang, Shenhai
Henry M
Degrad, Sylvia Giouanna
Chiao, Xiao
Chin, Ji Yuin
Matsuzora, Robert Day, Giunia
Yui, Yong Noon
McCormick, Kevin Day
Paranai, Anandang
Xiao, Dawn
Aslanian, Robert Giyogi
Woo, Jie
Lao, Ashwin Umetsushiyu
Sirih Ivan, Huyen
Method, Joey Lee
The Yarn, Horn The Yuin
Kelly, Elizabeth Helen
Brown, William Colby
Jean, Chin
Gooan, Giorricia Polyvina
Ray Hein, Andrew Jei
Bijyu, Pratsk Quatre Jeanny
Dawn Day, Pawan Kay
Don Lee
Huber, Salem
Huang, Shenhai
Henry M
Application Number:
JP2013546270A
Publication Date:
July 13, 2016
Filing Date:
December 19, 2011
Export Citation:
Assignee:
Merck Sharp & Dohme Corp.
International Classes:
C07D241/42; A61K31/498; A61K31/4985; A61K31/4995; A61K31/5377; A61K31/55; A61K31/551; A61P11/00; A61P11/02; A61P11/06; A61P37/08; A61P43/00; C07D401/06; C07D401/12; C07D401/14; C07D403/06; C07D403/12; C07D403/14; C07D405/12; C07D409/12; C07D413/06; C07D413/12; C07D413/14; C07D417/12; C07D417/14; C07D451/02; C07D471/04; C07D471/08; C07D471/10; C07D487/04; C07D487/08; C07D491/107; C07D498/04; C07D498/10
Domestic Patent References:
| JP2007509114A | ||||
| JP2006511486A |
Foreign References:
| WO2010074244A1 | ||||
| WO2005123731A1 | ||||
| WO2008119917A1 |
Attorney, Agent or Firm:
Yoshikazu Iwase
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Yasufumi Shiroyama
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Yasufumi Shiroyama