Title:
クオラムセンシング細菌におけるコミュニケーション及び毒性を変更するための化合物及び方法
Document Type and Number:
Japanese Patent JP5133067
Kind Code:
B2
Abstract:
The present invention provides compositions and methods for modulating the communication and virulence of quorum sensing bacteria. In various exemplary embodiments, the invention provides a combinatorial library of quorum sensing compounds including synthetic analogs of naturally occurring and non-naturally occurring acyl-homoserine lactone (AHL) analogs, and methods of synthesizing and using these compounds.
Inventors:
Blackwell, Helen Yi.
Guess, Grant Dee.
Weezman, Raquel Jay.
Guess, Grant Dee.
Weezman, Raquel Jay.
Application Number:
JP2007554210A
Publication Date:
January 30, 2013
Filing Date:
February 02, 2006
Export Citation:
Assignee:
WISCONSIN ALUMNI RESEARCH FOUNDATION
International Classes:
C07D307/33; A61K31/341; A61K31/351; A61K31/4025; A61K31/405; A61K31/496; A61P31/04; C07D309/30; C07D405/12
Domestic Patent References:
| JP6506588A |
Other References:
MARTINELLI,D. et al,Effects of natural and chemically synthesized furanones on quorum sensing in Chromobacterium violaceum,BMC Microbiology,2004年,Vol.4,p.1-10
SCHAEFER,A.L. et al,Long-chain acyl-homoserine lactone quorum-sensing regulation of Rhodobacter capsulatus gene transfer agent production,Journal of Bacteriology,2002年,Vol.184, No.23,p.6515-6521
ZHU,J. et al,Agrobacterium bioassay strain for ultrasensitive detection of N-acylhomoserine lactone-type quorum-sensing molecules: Detection of autoinducers in Mesorhizobium huakuii,Applied and Environmental Microbiology,2003年,Vol.69, No.11,p.6949-6953
CHHABRA,S.R. et al,Synthetic Analogues of the Bacterial Signal (Quorum Sensing) Molecule N-(3-Oxododecanoyl)-L-homoserine Lactone as Immune Modulators,Journal of Medicinal Chemistry,2003年,Vol.46, No.1,p.97-104
YATES,E.A. et al,N-acylhomoserine lactones undergo lactonolysis in a pH-, temperature-, and acyl chain length-dependent manner during growth of Yersinia pseudotuberculosis and Pseudomonas aeruginosa,Infection and Immunity,2002年,Vol.70, No.10,p.5635-5646
REVERCHON,S. et al,New synthetic analogues of N-acyl homoserine lactones as agonists or antagonists of transcriptional regulators involved in bacterial quorum sensing,Bioorganic & Medicinal Chemistry Letters,2002年,Vol.12, No.8,p.1153-1157
SCHAEFER,A.L. et al,Quorum sensing in Vibrio fischeri: probing autoinducer-LuxR interactions with autoinducer analogs,Journal of Bacteriology,1996年,Vol.178, No.10,p.2897-2901
SCHAEFER,A.L. et al,Long-chain acyl-homoserine lactone quorum-sensing regulation of Rhodobacter capsulatus gene transfer agent production,Journal of Bacteriology,2002年,Vol.184, No.23,p.6515-6521
ZHU,J. et al,Agrobacterium bioassay strain for ultrasensitive detection of N-acylhomoserine lactone-type quorum-sensing molecules: Detection of autoinducers in Mesorhizobium huakuii,Applied and Environmental Microbiology,2003年,Vol.69, No.11,p.6949-6953
CHHABRA,S.R. et al,Synthetic Analogues of the Bacterial Signal (Quorum Sensing) Molecule N-(3-Oxododecanoyl)-L-homoserine Lactone as Immune Modulators,Journal of Medicinal Chemistry,2003年,Vol.46, No.1,p.97-104
YATES,E.A. et al,N-acylhomoserine lactones undergo lactonolysis in a pH-, temperature-, and acyl chain length-dependent manner during growth of Yersinia pseudotuberculosis and Pseudomonas aeruginosa,Infection and Immunity,2002年,Vol.70, No.10,p.5635-5646
REVERCHON,S. et al,New synthetic analogues of N-acyl homoserine lactones as agonists or antagonists of transcriptional regulators involved in bacterial quorum sensing,Bioorganic & Medicinal Chemistry Letters,2002年,Vol.12, No.8,p.1153-1157
SCHAEFER,A.L. et al,Quorum sensing in Vibrio fischeri: probing autoinducer-LuxR interactions with autoinducer analogs,Journal of Bacteriology,1996年,Vol.178, No.10,p.2897-2901
Attorney, Agent or Firm:
Takao Kawasaki
Toshizo Iida
Toshizo Iida