Title:
(R)-(-)-3-(カルバモイルメチル)-5-メチルヘキサン酸及びプレガバリン及び合成中間体の製法
Document Type and Number:
Japanese Patent JP2009542615
Kind Code:
A
Abstract:
This invention relates to the preparation of (R)-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid, in particular, the resolution of the acid racemate by means of salification with optically active amines and subsequent acidification to give the (R) enantiomer of the acid; this invention also concerns the salt intermediates formed with said amines and the conversion of said (R)-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid into biologically active molecules such as pregabalin.
Inventors:
Annivale Salvi
Antonio Nardi
Bruno de Angelis
Antonio Nardi
Bruno de Angelis
Application Number:
JP2009517463A
Publication Date:
December 03, 2009
Filing Date:
June 06, 2007
Export Citation:
Assignee:
Laboratorio Kimiko Internazionale Sochieta Per Azioni
International Classes:
C07C231/20; C07B57/00; C07C227/04; C07C229/08; C07C231/12; C07C231/22; C07C233/56
Domestic Patent References:
| JPH11506098A | 1999-06-02 | |||
| JP2003515578A | 2003-05-07 | |||
| JPS5829719A | 1983-02-22 | |||
| JPS6013736A | 1985-01-24 | |||
| JP2004217608A | 2004-08-05 |
Other References:
JPN7012003201; Ｏｒｇａｎｉｃ Ｐｒｏｃｅｓｓ Ｒｅｓｅａｃｈ ａｎｄ Ｄｅｖｅｌｏｐｍｅｎｔ １, 1997, ２６-３８
Attorney, Agent or Firm:
Soichi Takezawa
Noritsugu Nakama
Hiroyuki Mori
Noritsugu Nakama
Hiroyuki Mori