(R)-(-)-3-(カルバモイルメチル)-5-メチルヘキサン酸及びプレガバリン及び合成中間体の製法 - Laboratorio Kimiko Internazionale Sochieta Per Azioni

Title:

(R)-(-)-3-(カルバモイルメチル)-5-メチルヘキサン酸及びプレガバリン及び合成中間体の製法

Document Type and Number:

Japanese Patent JP5202519

Kind Code:

B2

Abstract:

This invention relates to the preparation of (R)-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid, in particular, the resolution of the acid racemate by means of salification with optically active amines and subsequent acidification to give the (R) enantiomer of the acid; this invention also concerns the salt intermediates formed with said amines and the conversion of said (R)-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid into biologically active molecules such as pregabalin.

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Inventors:

Annivale Salvi
Antonio Nardi
Bruno de Angelis

Application Number:

JP2009517463A

Publication Date:

June 05, 2013

Filing Date:

June 06, 2007

Export Citation:

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Assignee:

Laboratorio Kimiko Internazionale Sochieta Per Azioni

International Classes:

C07C231/20; C07C227/04; C07C229/08; C07C231/12; C07C231/22; C07C233/56; C07B57/00

Domestic Patent References:

JP11506098A
JP2003515578A
JP58029719A
JP60013736A
JP2004217608A

Other References:

Organic Process Reseach and Development,1997年,1,26-38

Attorney, Agent or Firm:

Soichi Takezawa
Noritsugu Nakama
Hiroyuki Mori

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