Title:
RA抗原ペプチド
Document Type and Number:
Japanese Patent JP4532486
Kind Code:
B2
Abstract:
The present invention provides novel naturally-processed MHC class II antigenic peptides; which originate from interferon-gamma-inducible lysosomal thiol reductase, integrin beta-2, phosphatitylinositol-4,5-bisphosphate 3-kinase, urokinase-type plas-minogen activator, immunoglobulin heavy chain V-III region (VH26), DJ-1 protein, apolipoprotein B-100, 26S proteasome non-AT-Pase regulatory subunit 8, interleukin-1 receptor, fibromodulin, GM-CSF/IL-3/IL-5 receptor, sorting nexin 3, inter-alpha-trypsin inhibitor heavy chain H4, complement C4, complement C3 (alpha-chain), complement C3 (beta-chain), SH3 domain-binding glutamic acid-rich-like protein 3, interleukin-4-induced protein 1, hemopexin, Hsc70-interacting protein, invariant chain (Ii), retinoic acid receptor responder protein 2, fibronectin, cathepsin B, tripeptidyl-peptidase II, legumain, platelet activating factor receptor, poly-alpha-2.8-sialyltrans-ferase, and ras-leated protein Rab-11B. Also provided are these antigenic peptides and the proteins they are derived from as markers for erosive and/or non-erosive RA. Moreover, these antigenic peptides linked to MHC class II molecules, antibodies reactive with said antigenic peptides, nucleic acids encoding said antigenic peptides, and nucleic acid constructs, host cells and methods for expressing said antigenic peptides are provided. The antigenic peptides of the invention can be used as markers in diagnosis of RA and in therapy as anti-RA vaccines.
Inventors:
Burn Tennis Nicholas
Bourgmann Gerrit
Cropshofer Harald
Mueller Bernd Christian
Spin del doller sebastian thomas
Vogt Anne
Zorg Warner
Bourgmann Gerrit
Cropshofer Harald
Mueller Bernd Christian
Spin del doller sebastian thomas
Vogt Anne
Zorg Warner
Application Number:
JP2006522303A
Publication Date:
August 25, 2010
Filing Date:
July 30, 2004
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C12N15/09; A61K39/00; A61K39/395; C07K4/12; C07K14/47; C07K14/74; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02
Domestic Patent References:
| JP2004123749A |
Other References:
Science,1995,Vol.270,p.1357-1359
Gamma-interferon inducible lysosomal thiol reductase precursor,NCBI Protein Database,2001年,ACCESSION:P13284,URL,http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?12643406:OLD03:5709148
J.Exp.Med.,1993年,Vol.178,p.27-47
Gamma-interferon inducible lysosomal thiol reductase precursor,NCBI Protein Database,2001年,ACCESSION:P13284,URL,http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?12643406:OLD03:5709148
J.Exp.Med.,1993年,Vol.178,p.27-47
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi