短干渉核酸(siNA)を用いるインターロイキン遺伝子発現のRNA干渉媒介性阻害

Japanese Patent JP2005524393

A

The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), doublestranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.

James, Maxwigen
Bjellman, Leonide
James, Thompson

JP2003569651A

August 18, 2005

February 11, 2003

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Sirna Therapeutics,Inc.

C12N15/09; A61K31/7088; A61K31/7105; A61K31/711; A61K31/7115; A61K31/712; A61K31/7125; A61K31/713; A61K47/48; A61K48/00; A61P1/00; A61P1/04; A61P1/16; A61P3/00; A61P3/10; A61P11/06; A61P13/08; A61P13/10; A61P13/12; A61P17/00; A61P17/02; A61P19/00; A61P19/02; A61P21/00; A61P25/00; A61P25/02; A61P25/28; A61P27/02; A61P27/16; A61P29/00; A61P31/00; A61P31/04; A61P31/10; A61P31/12; A61P31/14; A61P31/16; A61P31/18; A61P31/20; A61P31/22; A61P35/00; A61P35/02; A61P37/00; A61P37/04; A61P37/06; A61P37/08; A61P43/00; C07H21/02; C07H21/04; C12N15/11; C12N15/113; C12N15/82; A61K38/00; (IPC1-7): C12N15/09; A61P1/00; A61P1/04; A61P1/16; A61P3/10; A61P11/06; A61P13/08; A61P13/10; A61P13/12; A61P17/00; A61P17/02; A61P19/00; A61P19/02; A61P21/00; A61P25/00; A61P25/02; A61P25/28; A61P27/02; A61P27/16; A61P29/00; A61P31/00; A61P31/04; A61P31/12; A61P31/18; A61P35/00; A61P37/04; A61P37/06; A61P37/08

Seiji Ohno
Koji Morita
Reiko Tanaka
Ken Kitano

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