Title:
ＧＳＴ−π遺伝子を調節するためのＲＮＡ干渉剤
Document Type and Number:
Japanese Patent JP6457645
Kind Code:
B2
Abstract:
This invention provides compositions for use in distributing active agents for treating a malignant tumor in a subject. The compositions contain RNAi molecules targeted to a human GST-π, along with RNAi molecules targeted to a human p21, and a pharmaceutically acceptable carrier. The carrier can include nanoparticles composed of an ionizable lipid, a structural lipid, one or more stabilizer lipids, and a lipid for reducing immunogenicity of the nanoparticles. This invention further provides methods for preventing or treating a malignant tumor by administering a therapeutically effective amount of an RNAi composition
Inventors:
Inn, Wenbin
Kenjiro Miso
Harbour, Jens
Hirokazu Takahashi
Erika Terada
Jun, Jun
Ahmadian, Mohammed
Kenjiro Miso
Harbour, Jens
Hirokazu Takahashi
Erika Terada
Jun, Jun
Ahmadian, Mohammed
Application Number:
JP2017534297A
Publication Date:
January 23, 2019
Filing Date:
December 28, 2015
Export Citation:
Assignee:
NITTO DENKO CORPORATION
International Classes:
C12N15/113; A61K9/127; A61K31/713; A61K47/24; A61K47/28; A61K48/00; A61P35/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10
Domestic Patent References:
| JP2018512373A | ||||
| JP2018513669A | ||||
| JP2013212113A | ||||
| JP2009513151A | ||||
| JP2009536827A |
Foreign References:
| WO2012176282A1 | ||||
| WO2014098210A1 |
Other References:
Carcinogenesis,2008年,vol.29, no.6,p.1134-1138
Proc. Natl. Acad. Sci. USA,2010年,vol.107,p.2503-2508
Gene,1989年,vol.75,p.3-11
Biochem. Biophys. Res. Commun.,2014年,vol.447,p.77-82
Proc. Natl. Acad. Sci. USA,2010年,vol.107,p.2503-2508
Gene,1989年,vol.75,p.3-11
Biochem. Biophys. Res. Commun.,2014年,vol.447,p.77-82
Attorney, Agent or Firm:
Hiraki International Patent Office