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Title:
組合せ抗癌療法のためのRNAワクチン及び免疫チェックポイント阻害剤
Document Type and Number:
Japanese Patent JP2020514370
Kind Code:
A
Abstract:
本発明は、生物医学の分野、特に治療用核酸の分野に関する。本発明は、エピトープをコードするRNAと免疫チェックポイント阻害剤との新規な組合せを提供する。前記組合せを含む医薬組成物、ワクチン、及びキットオブパーツも提供する。更に、本発明は、医学、特に癌、感染症、並びに他の疾患及び障害の治療及び/又は予防に使用するための組合せ、(医薬)組成物、ワクチン、又はキットオブパーツに関する。【選択図】図1

Inventors:
Regina Heidenreich
Kacha Fiedler
Mariora fotin-muretek
Alexandra Kovalchic
Knut Elbers
Melanie Wurm
Application Number:
JP2019550823A
Publication Date:
May 21, 2020
Filing Date:
March 16, 2018
Export Citation:
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Assignee:
Cure Back Age
Boehringer Ingelheim International GmbH
International Classes:
A61K39/00; A61K31/7088; A61K31/7105; A61K39/395; A61K45/06; A61K48/00; A61P31/00; A61P35/00; A61P35/02; A61P37/04; A61P37/06; A61P37/08; A61P43/00; C07K14/705; C07K16/28; C12N15/11; C12N15/113; C12N15/115; C12N15/12; C12N15/13; C12N15/62
Domestic Patent References:
JP2016514097A2016-05-19
Other References:
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GODING, S. R. ET AL.: "Restoring immune function of tumor-specific CD4+ T cells during recurrence of melanoma", JOURNAL OF IMMUNOLOGY, vol. 190, no. 9, JPN6022008055, 2013, pages 4899 - 4909, XP055145038, ISSN: 0004909833, DOI: 10.4049/jimmunol.1300271
WOO, S. R. ET AL.: "Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumor", CANCER RESEARCH, vol. 72, no. 4, JPN6022008054, 2012, pages 917 - 927, XP055431013, ISSN: 0004909830, DOI: 10.1158/0008-5472.CAN-11-1620
SHARMA, P. ET AL.: "Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy", CELL, vol. 168, no. 4, JPN6022045400, 9 February 2017 (2017-02-09), pages 707 - 723, XP029935389, ISSN: 0004909831, DOI: 10.1016/j.cell.2017.01.017
Attorney, Agent or Firm:
Koichi Hirota
Yoshihiro Nagare
Naoko Matsuda