Title:
RORC2 prevention medicine and directions for use for the same
Document Type and Number:
Japanese Patent JP6224832
Kind Code:
B2
Abstract:
The present invention provides compounds, pharmaceutical compositions, methods of inhibiting RORy activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such compounds and pharmaceutical compositions.
Inventors:
James Robert Bryn
Andrew Christopher Flick
Golan Matthias Vennethal
Peter Jones
Neilou Kaila
James Richard Kiefer Jr.
Ravi Gee. Krumbale
Scott Richard Maintain
Marvin Jay Myers
Mark edward schnute
Atris poralensen
Lee Shin
Eduardo The Maratsuki
Christoph Wolfgang Zaype
Andrew Christopher Flick
Golan Matthias Vennethal
Peter Jones
Neilou Kaila
James Richard Kiefer Jr.
Ravi Gee. Krumbale
Scott Richard Maintain
Marvin Jay Myers
Mark edward schnute
Atris poralensen
Lee Shin
Eduardo The Maratsuki
Christoph Wolfgang Zaype
Application Number:
JP2016530640A
Publication Date:
November 01, 2017
Filing Date:
July 24, 2014
Export Citation:
Assignee:
Pfizer Inc.
International Classes:
C07D401/04; A61K31/454; A61K31/4545; A61K31/497; A61K31/506; A61P1/04; A61P1/16; A61P3/10; A61P7/02; A61P11/00; A61P11/06; A61P17/00; A61P17/06; A61P19/00; A61P19/02; A61P21/00; A61P21/04; A61P25/00; A61P29/00; A61P37/06; A61P37/08; A61P43/00; C07D401/14; C07D403/14; C07D405/14; C07D413/14; C07D417/14
Domestic Patent References:
| JP63225374A | ||||
| JP2000516233A | ||||
| JP11502816A | ||||
| JP2001503774A | ||||
| JP2005513016A | ||||
| JP2001512727A |
Foreign References:
| WO1999064044A1 | ||||
| WO2012139775A1 | ||||
| WO2013064231A1 | ||||
| WO2014028597A1 |
Other References:
FORBES I T,CCR2B RECEPTOR ANTAGONISTS: CONVERSION OF A WEAK HTS HIT TO A POTENT LEAD COMPOUND,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,NL,PERGAMON,2000年 8月21日,VOL:10, NR:16,,PAGE(S):1803 - 1806,URL,http://dx.doi.org/10.1016/S0960-894X(00)00347-4
SANDRA A FILLA,NOVEL POTENT 5-HT1F RECEPTOR AGONISTS: STRUCTURE-ACTIVITY STUDIES OF A SERIES OF 以下備考,JOURNAL OF MEDICINAL CHEMISTRY,米国,AMERICAN CHEMICAL SOCIETY,2003年 6月 3日,VOL:46, NR:14,,PAGE(S):3060 - 3071,SUBSTITUTED N-[3-(1-METHYL-4-PIPERIDINYL)-1H-PYRROLO[3,2-B]PYRIDIN-5-YL]AMIDES,URL,http://dx.doi.org/10.1021/jm030020m
ZHANG D,DESIGN, SYNTHESIS AND EVALUATION OF BICYCLIC BENZAMIDES AS NOVEL 5-HT1F RECEPTOR AGONISTS,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,NL,PERGAMON,2004年12月20日,VOL:14, NR:24,,PAGE(S):6011 - 6016,URL,http://dx.doi.org/10.1016/j.bmcl.2004.09.079
Journal of Medicinal Chemistry,2005年,Vol.48, No.13,p.4216-4219
SANDRA A FILLA,NOVEL POTENT 5-HT1F RECEPTOR AGONISTS: STRUCTURE-ACTIVITY STUDIES OF A SERIES OF 以下備考,JOURNAL OF MEDICINAL CHEMISTRY,米国,AMERICAN CHEMICAL SOCIETY,2003年 6月 3日,VOL:46, NR:14,,PAGE(S):3060 - 3071,SUBSTITUTED N-[3-(1-METHYL-4-PIPERIDINYL)-1H-PYRROLO[3,2-B]PYRIDIN-5-YL]AMIDES,URL,http://dx.doi.org/10.1021/jm030020m
ZHANG D,DESIGN, SYNTHESIS AND EVALUATION OF BICYCLIC BENZAMIDES AS NOVEL 5-HT1F RECEPTOR AGONISTS,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,NL,PERGAMON,2004年12月20日,VOL:14, NR:24,,PAGE(S):6011 - 6016,URL,http://dx.doi.org/10.1016/j.bmcl.2004.09.079
Journal of Medicinal Chemistry,2005年,Vol.48, No.13,p.4216-4219
Attorney, Agent or Firm:
Noh four
Junko Miyazawa
Maki Sato
Tatsuta Miyuki
Junko Miyazawa
Maki Sato
Tatsuta Miyuki