Title:
Ｆａｃｔｏｒ ＶＩＩＩ又はＦａｃｔｏｒ ＩＸ遺伝子がノックアウトされたウサギ、その製造方法及びその用途
Document Type and Number:
Japanese Patent JP7091450
Kind Code:
B2
Abstract:
The present invention relates to a factor VIII or factor IX gene knockout rabbit, a method for preparing the same and a use thereof and, more particularly, to a transgenic rabbit whose factor VIII or factor IX gene has been knocked out through the CRISPR/Cas9 system, a method for preparing the same and a use thereof. According to the present invention, in the transgenic rabbit, whose factor VIII and/or factor IX gene has been knocked out, the functions of factor VIII and/or factor IX, which are proteins that perform critical functions for the development of hemophilia, are inhibited, such that the transgenic rabbit is useful for the development of hemophilia treatments.
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Inventors:
Kim Sora
Jeong Myung Eun
Kim Min Chung
Chosun Hyun
Hon Sung Ho
Kwak Hichon
Lee Soo Min
Nam Hyun Cha
Jeong Myung Eun
Kim Min Chung
Chosun Hyun
Hon Sung Ho
Kwak Hichon
Lee Soo Min
Nam Hyun Cha
Application Number:
JP2020518017A
Publication Date:
June 27, 2022
Filing Date:
September 20, 2018
Export Citation:
Assignee:
Green Cross Corporation
MOGAM Institute for Biomedical Research
MOGAM Institute for Biomedical Research
International Classes:
C12N15/09; A01K67/027; C12N5/10; C12N15/11
Foreign References:
| WO2017112895A1 |
Other References:
Thrombosis Journal,2016年,vol.14, article no.22, p.101-106
"Oryctolagus cuniculus coagulation factor VIII (F8), mRNA", GenBank [online], 2016年6月26日, Accession No.NM_001171271, [2021年6月28日検索], インターネット
"Oryctolagus cuniculus coagulation factor VIII (F8), mRNA", GenBank [online], 2016年6月26日, Accession No.NM_001171271, [2021年6月28日検索], インターネット
Attorney, Agent or Firm:
Kenjiro Yamaguchi
Hironori Nagayama
Kenichi Morita
Hironori Nagayama
Kenichi Morita