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Title:
RACEMIC SEPARATION OF 2,6-TRANS-DIMETHYLMORPHOLINE
Document Type and Number:
Japanese Patent JP2014012713
Kind Code:
A
Abstract:

To provide a method of producing optically active trans-2,6-dimethylmorpholine.

A method of producing optically active trans-2,6-dimethylmorpholine comprises steps of: (i) reacting racemic trans-2,6-dimethylmorpholine with D-mandelic acid; (ii) separating a salt, formed from D-mandelic acid and one enantiomer of the trans-2,6-dimethylmorpholine, from the other enantiomer of the trans-2,6-dimethylmorpholine by precipitation and taking out the salt; and (iii) isolating desired optically active trans-2,6-dimethylmorpholine.


Inventors:
Ditrich, Klaus
Frank, Haese
Application Number:
JP2013000184614
Publication Date:
January 23, 2014
Filing Date:
September 06, 2013
Export Citation:
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Assignee:
BASF SE
International Classes:
C07D265/30; C07B57/00
Domestic Patent References:
JP2003514888A2003-04-22
JP2009522229A2009-06-11
Foreign References:
Other References:
JPN5008022213; EMANUELA LICANDRO: TETRAHEDRON ASYMMETRY V11, 2000, P975-980
JPN6012041724; LICANDRO,E. et al: 'Asymmetric synthesis of (-)-(2R,6R)-2,6-dimethylmorpholine' Tetrahedron: Asymmetry Vol.6, No.8, 1995, p.1891-1894
JPN6011042700; 光学異性体の分離〔季刊 化学総説 No.6〕 3刷, 19990610, p.45-54, 株式会社 学会出版センター
Attorney, Agent or Firm:
平木 祐輔
藤田 節
新井 栄一
田中 夏夫