Title:
RACEMIC SEPARATION OF 2,6-TRANS-DIMETHYLMORPHOLINE
Document Type and Number:
Japanese Patent JP2014012713
Kind Code:
A
Abstract:
To provide a method of producing optically active trans-2,6-dimethylmorpholine.
A method of producing optically active trans-2,6-dimethylmorpholine comprises steps of: (i) reacting racemic trans-2,6-dimethylmorpholine with D-mandelic acid; (ii) separating a salt, formed from D-mandelic acid and one enantiomer of the trans-2,6-dimethylmorpholine, from the other enantiomer of the trans-2,6-dimethylmorpholine by precipitation and taking out the salt; and (iii) isolating desired optically active trans-2,6-dimethylmorpholine.
Inventors:
DITRICH KLAUS
FRANK HAESE
FRANK HAESE
Application Number:
JP2013184614A
Publication Date:
January 23, 2014
Filing Date:
September 06, 2013
Export Citation:
Assignee:
BASF SE
International Classes:
C07D265/30; C07B57/00
Domestic Patent References:
| JP2003514888A | 2003-04-22 | |||
| JP2009522229A | 2009-06-11 |
Other References:
JPN5008022213; ＥＭＡＮＵＥＬＡ ＬＩＣＡＮＤＲＯ: ＴＥＴＲＡＨＥＤＲＯＮ ＡＳＹＭＭＥＴＲＹ Ｖ１１, 2000, Ｐ９７５-９８０
JPN6012041724; ＬＩＣＡＮＤＲＯ，Ｅ． ｅｔ ａｌ: 'Ａｓｙｍｍｅｔｒｉｃ ｓｙｎｔｈｅｓｉｓ ｏｆ （-）-（２Ｒ，６Ｒ）-２，６-ｄｉｍｅｔｈｙｌｍｏｒｐｈｏｌｉｎｅ' Ｔｅｔｒａｈｅｄｒｏｎ： Ａｓｙｍｍｅｔｒｙ Ｖｏｌ．６， Ｎｏ．８, 1995, ｐ．１８９１-１８９４
JPN6011042700; 光学異性体の分離〔季刊 化学総説 Ｎｏ．６〕 ３刷, 19990610, ｐ．４５-５４, 株式会社 学会出版センター
JPN6012041724; ＬＩＣＡＮＤＲＯ，Ｅ． ｅｔ ａｌ: 'Ａｓｙｍｍｅｔｒｉｃ ｓｙｎｔｈｅｓｉｓ ｏｆ （-）-（２Ｒ，６Ｒ）-２，６-ｄｉｍｅｔｈｙｌｍｏｒｐｈｏｌｉｎｅ' Ｔｅｔｒａｈｅｄｒｏｎ： Ａｓｙｍｍｅｔｒｙ Ｖｏｌ．６， Ｎｏ．８, 1995, ｐ．１８９１-１８９４
JPN6011042700; 光学異性体の分離〔季刊 化学総説 Ｎｏ．６〕 ３刷, 19990610, ｐ．４５-５４, 株式会社 学会出版センター
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
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