Title:
組織および臓器の治療および修復に用いるための幹細胞マトリックスの迅速な調製方法
Document Type and Number:
Japanese Patent JP4680483
Kind Code:
B2
Abstract:
The present invention describes a rapid method for preparing stem cell and physiologically acceptable matrix compositions for use in tissue and organ repair. Compared with previous tissue engineering materials, the stem cell-matrix compositions of the present invention do not require long-term incubation or cultivation in vitro prior to use in in vivo applications. The stem cells can be from numerous sources and may be homogeneous, heterogeneous, autologous, and/or allogeneic in the matrix material. The stem cell-matrix compositions as described provide point of service utility for the practitioner, wherein the stem cells and matrix can be combined not long before use, thereby alleviating costly and lengthy manufacturing procedures. In addition, the stem cells offer unique structural properties to the matrix composition which improves outcome and healing after use. Use of stem cells obtained from muscle affords contractility to the matrix composition.
Inventors:
Chancellor Michael Bee.
Your Johnny
Caperry christopher
Chan Steve
Saxophone Michael S.
Your Johnny
Caperry christopher
Chan Steve
Saxophone Michael S.
Application Number:
JP2002567239A
Publication Date:
May 11, 2011
Filing Date:
February 22, 2002
Export Citation:
Assignee:
University of Pittsburgh of the Commonwealth System of Higher Education
International Classes:
A61L27/00; C12N11/02; A61L27/38; C12N5/00; C12N5/07; C12N5/077; A61K35/12
Domestic Patent References:
| JP9500040A |
Foreign References:
| WO1999056785A1 | ||||
| WO2000029552A1 |
Other References:
The Journal of Cell Biology, 152 (2001 Jan.) p.335-348
The Journal of Urology, 165 (2001 Jan.) p.271-276
Developmental Biology, Vol.218, pp.115-124 (2000)
The Journal of Urology, Vol.164, pp.928-935 (2000)
Tissue Engineering, Vol.4, pp.379-387 (1998)
Biomaterials, Vol.27, pp.2398-2404 (2006)
Biomaterials, Vol.26, pp.443-449 (2005)
The Journal of Urology, 165 (2001 Jan.) p.271-276
Developmental Biology, Vol.218, pp.115-124 (2000)
The Journal of Urology, Vol.164, pp.928-935 (2000)
Tissue Engineering, Vol.4, pp.379-387 (1998)
Biomaterials, Vol.27, pp.2398-2404 (2006)
Biomaterials, Vol.26, pp.443-449 (2005)
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi