Title:
迅速に作用する薬物送達組成物
Document Type and Number:
Japanese Patent JP5272086
Kind Code:
B2
Abstract:
Drug formulations for systemic drug delivery with improved stability and rapid onset of action are described herein. The formulations are administered sublingually or via subcutaneous injection. The formulations contain an active agent and one or more excipients, selected to increase the rate of dissolution. In the preferred embodiment, the drug is insulin, and the excipients include a zinc metal chelator such as EDTA and a solubilizing acid such as acetic acid, ascorbic acid, or citric acid.
Inventors:
Roderick paul
Solomon S. Steiner
Solomon S. Steiner
Application Number:
JP2012021473A
Publication Date:
August 28, 2013
Filing Date:
February 03, 2012
Export Citation:
Assignee:
Biodell, Inc.
International Classes:
A61K38/28; A61K9/00; A61K9/14; A61K9/20; A61K9/48; A61K38/00; A61K38/18; A61K38/19; A61K38/20; A61K38/22; A61K38/23; A61K38/26; A61K38/27; A61K38/29; A61K47/06; A61K47/12; A61K47/18; A61P3/08
Domestic Patent References:
| JP2000502993A |
Foreign References:
| WO2002076495A1 |
Other References:
AAPS PharmSciTech,2003年,Vol.4 , No.2,pp.1-12
日本薬学会第121年会要旨集3,2001年,p.119(PE II-053)
International Journal of Pharmaceutics,2003年,Vol.254,pp.271-280
Pharmaceutical Research,1991年,Vol.8 , No.7,pp.925-929
International Journal of Pharmaceutics,2001年,Vol.217,pp.71-78
Journal of Colloid and Interface Science,1988年,Vol.122 , No.2,pp.557-566
Journal of Pharmaceutical Sciences,1983年,Vol.72 , No.1,pp.75-78
日本薬学会第121年会要旨集3,2001年,p.119(PE II-053)
International Journal of Pharmaceutics,2003年,Vol.254,pp.271-280
Pharmaceutical Research,1991年,Vol.8 , No.7,pp.925-929
International Journal of Pharmaceutics,2001年,Vol.217,pp.71-78
Journal of Colloid and Interface Science,1988年,Vol.122 , No.2,pp.557-566
Journal of Pharmaceutical Sciences,1983年,Vol.72 , No.1,pp.75-78
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita