Title:
トリフルオロメチル化用反応試剤
Document Type and Number:
Japanese Patent JP5189345
Kind Code:
B2
Abstract:
Provided is a reaction reagent for trifluoromethylation with high general versatility and good efficiency. The reaction reagent for trifluoromethylation contains an iron compound, trifluoromethyl iodide, a sulfoxide and a peroxide, and may further contain an acid. The iron compound is, for example, iron(II) sulfate, ammonium iron(II) sulfate, iron(II) tetrafluoroborate, ferrocene, bis(· 5 -pentamethylcyclopentadienyl)iron or an iron powder; the sulfoxide is, for example, dimethyl sulfoxide; the peroxide is, for example, hydrogen peroxide or hydrogen peroxide-urea composite; and the acid is, for example, sulfuric acid, tetrafluoroboric acid or trifluoromethanesulfonic acid.
Inventors:
Yamakawa Satoshi
Kyoko Yamamoto
Uraguchi Daisuke
Kenji Tokuhisa
Kyoko Yamamoto
Uraguchi Daisuke
Kenji Tokuhisa
Application Number:
JP2007288135A
Publication Date:
April 24, 2013
Filing Date:
November 06, 2007
Export Citation:
Assignee:
Tosoh Corporation
Toso-F-Tech Co., Ltd.
Sagami Central Chemical Research Institute
Toso-F-Tech Co., Ltd.
Sagami Central Chemical Research Institute
International Classes:
C07C17/32; C07B37/04; C07C22/08; C07C209/68; C07C211/46; C07D213/64; C07D231/12; C07D239/46; C07D473/16; C07D473/18
Domestic Patent References:
| JP2007153876A |
Foreign References:
| WO2005054191A1 |
Other References:
J.Med.Chem.,(1997),40(11),p.1619-1633
Bioorg.Med.Chem.Lett.,(2006),16(14),p.3657-62
Bioorg.Med.Chem.Lett.,(2006),16(14),p.3657-62