Title:
REACTION VESSEL, AND METHOD AND APPARATUS FOR PRODUCING OPTICALLY ACTIVE ANTI-1,2-NITROALKANOL COMPOUND
Document Type and Number:
Japanese Patent JP2015209409
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a production method capable of continuously synthesizing an optically active anti-1,2-nitroalkanol compound highly anti-selectively with a very high asymmetric yield.SOLUTION: In a method for producing an optically active anti-1,2-nitroalkanol compound, a raw material mixture comprising an aldehyde compound such as 3-methoxy benzaldehyde, a nitroalkane compound having 2 or more carbon atoms such as nitroethane, and a catalyst obtained by mixing an optically active amide compound represented by structural formula (1), a neodymium-containing compound, a sodium-containing compound, and a carbon structure is continuously supplied to a reaction vessel 5, and the produced optically active anti-1,2-nitroalkanol compound is continuously extracted from the reaction vessel 5.
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Inventors:
SHIBAZAKI MASAKATSU
KUMAGAI NAOYA
HASHIMOTO KAZUKI
KUMAGAI NAOYA
HASHIMOTO KAZUKI
Application Number:
JP2014092452A
Publication Date:
November 24, 2015
Filing Date:
April 28, 2014
Export Citation:
Assignee:
INST OF MICROBIAL CHEMISTRY
International Classes:
C07C201/12; C07C205/32
Attorney, Agent or Firm:
Koichi Hirota
Yoshihiro Nagare
Naoko Matsuda
Yoshihiro Nagare
Naoko Matsuda