Title:
REAGENT FOR INSPECTING CELL REACTION AND USING METHOD THEREOF
Document Type and Number:
Japanese Patent JP3247916
Kind Code:
B2
Abstract:
PURPOSE: To obtain a stabilized inspection reagent for granular substance having high cell reactivity by composing the reagent of hydroxyapatite (HAp) particles having a specified particle size fired at a specified temperature.
CONSTITUTION: The reagent for inspecting cell reaction is composed of HAp particles having specified average particle size in the range of 0.5-5μm fired at a specified temperature. The particle size smaller than 0.5μm weakens stimulus to the cell and the particle size larger than 5μm is resistant against the cell thus also weakening stimulus to the cell. The firing temperature lower than 1000°C causes significant reduction of stimulus to the cell and the upper limit is set lower than the decomposition temperature of apatite. The reagent exhibits strong stimulus to the cell and facilitates sterilization under high temperature and removal of endotoxin. Furthermore, it is quite stable under normal temperature, and thereby it van be used as a standard reagent for inspecting the cell reaction.
Inventors:
Mitsuo Nagase
Hiroyasu Takeuchi
Toshiyuki Kurosawa
Yoshihiro Abe
Hajime Nishitani
Kimitoshi Noda
Hiroyasu Takeuchi
Toshiyuki Kurosawa
Yoshihiro Abe
Hajime Nishitani
Kimitoshi Noda
Application Number:
JP12755793A
Publication Date:
January 21, 2002
Filing Date:
May 28, 1993
Export Citation:
Assignee:
Mitsuo Nagase
Mitsubishi Materials Corporation
Mitsubishi Materials Corporation
International Classes:
C01B25/32; G01N33/49; G01N33/50; (IPC1-7): G01N33/49; C01B25/32; G01N33/50
Domestic Patent References:
| JP6276435A | ||||
| JP63284A |
Attorney, Agent or Firm:
Hajime Sakai
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