Title:
レシオ法を用いた細胞内酸素濃度測定試薬
Document Type and Number:
Japanese Patent JP6834112
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide a probe molecule having improved intracellular migration properties, and provide a luminescent reagent for quantifying oxygen concentrations in microenvironments such as cells, from a change of an emission spectrum, in real time with high sensitivity.SOLUTION: A compound contains at least one linker, at least one fluorophore, and at least one oxygen concentration-responsive phosphorophore. The fluorophore and the oxygen concentration-responsive phosphorophore are linked together through the linker, and the linker contains arginine.SELECTED DRAWING: Figure 6
Inventors:
Yoshihara Toshichu
Mami Ankagawa
Toshifumi Shigefumi
Mami Ankagawa
Toshifumi Shigefumi
Application Number:
JP2016205799A
Publication Date:
February 24, 2021
Filing Date:
October 20, 2016
Export Citation:
Assignee:
Gunma University
International Classes:
C07F15/00; C09K11/06; G01N21/78
Domestic Patent References:
| JP2015101570A |
Foreign References:
| WO2010044465A1 | ||||
| WO2010143172A1 | ||||
| WO2016075484A1 |
Other References:
Sensors,2015年,15,13503-13521
Angew. Chem. Int. Ed.,2012年,51,4148-4151
J. AM. CHEM. SOC. ,2005年,127,11851-11862
Bioconjugate Chem.,2011年,22,2507-2518
ChemBioChem,2012年,13,1184-1190
生物物理,2010年,50(3),137-140
Angew. Chem. Int. Ed.,2012年,51,4148-4151
J. AM. CHEM. SOC. ,2005年,127,11851-11862
Bioconjugate Chem.,2011年,22,2507-2518
ChemBioChem,2012年,13,1184-1190
生物物理,2010年,50(3),137-140
Attorney, Agent or Firm:
Yoshiyuki Kawaguchi
Shinichi Sanuki
Shinichi Sanuki