Title:
哺乳動物の変形性関節症及び関連する関節症状の治療に有用なＨＡＳ２及びルブリシンを含む骨保護遺伝子を発現する組換えＡＡＶベクター
Document Type and Number:
Japanese Patent JP7058603
Kind Code:
B2
Abstract:
The present disclosure relates to recombinant viral vectors, to pharmaceutical compositions comprising such recombinant vectors, and to methods for prevention and treatment of osteoarthritis in mammals. In particular, this disclosure provides adeno-associated virus (AAV) vectors capable of expressing, in a host, osteoprotective/chondroprotective bioactive proteins, including hyaluronan synthase 2 (HAS2) and lubricin (PRG4). Methods of production of these AAV are provided, as are methods of treatment of osteoarthritis in mammalian joints, by the long-term gene expression of osteoprotective/chondroprotective proteins, including HAS2 and PRG4, in both synovial and chondrocyte cells.
Inventors:
Diaz Figuei Red Monica
Kyostio-Moore Sirkka RM
Bathlet Patricia
Kyostio-Moore Sirkka RM
Bathlet Patricia
Application Number:
JP2018536882A
Publication Date:
April 22, 2022
Filing Date:
January 13, 2017
Export Citation:
Assignee:
Boehringer Ingelheim Animal Health USA Incorporated
GENZYME CORPORATION
GENZYME CORPORATION
International Classes:
C12N15/864; A61K35/76; A61K48/00; A61P19/02; C12N7/01; C12N15/54
Domestic Patent References:
| JP2003164289A |
Foreign References:
| US20080187576 | ||||
| WO2014205237A2 |
Other References:
久保俊一 他,関節疾患に対する遺伝子治療,The Bone,2000年,Vol. 14(3),pp. 357-363
Attorney, Agent or Firm:
Shinichiro Tanaka
Yoshi Kazuhiko Ta
Hiroyuki Suda
Kazuo Yamazaki
Satsuki Ichikawa
Hironobu Hattori
Toshio Takizawa
Yoshi Kazuhiko Ta
Hiroyuki Suda
Kazuo Yamazaki
Satsuki Ichikawa
Hironobu Hattori
Toshio Takizawa
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