組換えアビポックスウイルス

Japanese Patent JP3624911

B2

What is described is a modified vector, such as a recombinant poxvirus, particularly recombinant vaccinia virus, having enhanced safety. The modified recombinant virus has nonessential virus-encoded genetic functions inactivated therein so that virus has attenuated virulence. In one embodiment, the genetic functions are inactivated by deleting an open reading frame encoding a virulence factor. In another embodiment, the genetic functions are inactivated by insertional inactivation of an open reading frame encoding a virulence factor. What is also described is a vaccine containing the modified recombinant virus having nonessential virus-encoded genetic functions inactivated therein so that the vaccine has an increased level of safety compared to known recombinant virus vaccines.\!

Enzo Paoletti
Marion E Percus
Jill Taylor
James Tartagria
Elizabeth Kay Norton
Michelle Riviere
Charles de Taine
Keith Jay Linbach
Gerald P. Johnson
Stephen Epincus
William icocks
Jean-Christophe Francis
Russel robert getting

JP2003342873A

March 02, 2005

October 01, 2003

Click for automatic bibliography generation  

Virogenetics Corporation

A61K39/12; A61K39/08; A61K39/15; A61K39/165; A61K39/17; A61K39/175; A61K39/205; A61K39/21; A61K39/23; A61K39/245; A61K39/275; A61K39/285; A61K39/29; A61P31/04; A61P31/12; A61P31/14; A61P31/16; A61P31/18; A61P31/20; A61P31/22; C07H21/04; C07K1/00; C07K14/015; C07K14/02; C07K14/03; C07K14/035; C07K14/045; C07K14/05; C07K14/06; C07K14/065; C07K14/07; C07K14/11; C07K14/12; C07K14/125; C07K14/145; C07K14/15; C07K14/155; C07K14/16; C07K14/175; C07K14/18; C07K14/33; C12N7/00; C12N7/01; C12N7/04; C12N7/08; C12N15/00; C12N15/09; C12N15/86; C12N15/863; C12P21/06; A61K39/00; C12R1/93; (IPC1-7): C12N15/09; A61K39/275; A61P31/12; A61P31/14; A61P31/16; A61P31/18; A61P31/20; A61P31/22; C12N7/08

JP2500879A

Vaccine,Vol.6, pp.466-467 (1988)
Vaccine,Vol.6, pp.497-503 (1988)

Yanagita Seiji
Go Sakuma

Previous Patent: 調湿装置

Next Patent: 調湿装置