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Title:
低IgE結合性であり、T細胞抗原性の低下のない組換えアレルゲン
Document Type and Number:
Japanese Patent JP4508640
Kind Code:
B2
Abstract:
The present invention relates generally to reagents useful in the immunotherapeutic or immunoprophylactic treatment of allergic diseases. More particularly, the present invention provides modified allergens exhibiting reduced IgE interactivity including reduced IgE production-stimulatory activity, while retaining T-cell antigenicity, which are useful in the immunomodulation of type I allergic disease conditions. The present invention further contemplates a method of immunomodulation of allergic diseases such as type I allergic disease conditions by the administration of modified allergens exhibiting reduced IgE interactivity while retaining T-cell antigenicity.

Inventors:
Deweed Nicole
Shin, Mohan, Beer
Barra, Prem, Elle.
Swoboda, Ines
Application Number:
JP2003528855A
Publication Date:
July 21, 2010
Filing Date:
September 13, 2002
Export Citation:
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Assignee:
The University of Melbourne
International Classes:
C07K14/415; A61K39/36; C12N15/09; A61P37/08; C07K16/16; C12N15/13
Domestic Patent References:
JP8509966A
JP2002511842A
JP2002542783A
Other References:
Int. Arch. Allergy Immunol., 2001年1-3月(国立国会図書館, 2001年5月23日受入), vol. 124, p. 380-382
Mol. Immunol., 1998年4月, vol. 35, on. 5, p. 293-305
Eur. J. Immunol., 2002年, vol. 32, p. 270-280
Attorney, Agent or Firm:
Mizuno Yuuki