Title:
組換えヒトT2RNaseおよびその使用
Document Type and Number:
Japanese Patent JP5069562
Kind Code:
B2
Abstract:
The cloning and heterologous expression of human T2 RNase6PL are disclosed. Further disclosed are methods for preventing, inhibiting and/or reversing cell motility, actin filament assembly or disassembly, proliferation, colonization, differentiation, accumulation and/or development of abnormal cells in a subject is disclosed. The methods are effected by administering to the subject a therapeutically effective amount of a RNase6PL ribonuclease or close homologues thereof.
Inventors:
Lloyds, Revava
Schwartz, Betty
Smirnov, Patricia
Choseyov, Odedo
Schwartz, Betty
Smirnov, Patricia
Choseyov, Odedo
Application Number:
JP2007534175A
Publication Date:
November 07, 2012
Filing Date:
September 28, 2005
Export Citation:
Assignee:
Issam Research Development Company of the Hebrew University of Jerusalem
International Classes:
C12N15/09; A61K31/7105; A61K48/00; A61P35/00; A61P35/04; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/22
Domestic Patent References:
| JP2003508411A |
Other References:
Trubia,M. et al.,Ribonuclease T2 precursor (Ribonuclease 6).,Database DDBJ/EMBL/GenBank [online], Accessin No. O00584,2004年 6月15日,、[検索日2011.05.19]
Oncogene,2001年,Vol.20,p.980-988
Oncogene,2001年,Vol.20,p.980-988
Attorney, Agent or Firm:
Nobuaki Kazehaya
Noriko Asano
Noriko Asano