Title:
RECOMBINANT IMMUNOTOXIN TARGETING MESOTHELIN
Document Type and Number:
Japanese Patent JP2017140029
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a recombinant immunotoxin targetting mesothelin, which is a differentiation antigen present on the surface of ovarian cancer, mesothelioma, and several other types of human cancers.SOLUTION: According to the present invention, a chimeric molecule comprises a fusion polypeptide having the formula M-L1-FCS-FL-functional PE domain III. Here, M is an antibody that specifically binds to mesothelin, or a fragment thereof that specifically binds to mesothelin; L1 consists of from 1 to 10 continuous amino acid residues; FCS is a furin cleavage site consisting of continuous amino acid residues capable of being cleaved by furin; FL consists of from 3 to 8 continuous amino acid residues selected independently from glycine and serine.SELECTED DRAWING: Figure 3
More Like This:
Inventors:
IRA H PASTAN
JOHN WELDON
RICHARD BEERS
JOHN WELDON
RICHARD BEERS
Application Number:
JP2017043879A
Publication Date:
August 17, 2017
Filing Date:
March 08, 2017
Export Citation:
Assignee:
US GOV HEALTH & HUMAN SERVICES
International Classes:
C12N15/09; A61K38/16; A61K39/395; A61K47/68; A61P11/00; A61P15/00; A61P17/00; A61P35/00; A61P43/00; C07K14/21; C07K16/28; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10
Domestic Patent References:
| JP2008523105A | 2008-07-03 | |||
| JP2008526889A | 2008-07-24 | |||
| JP2009514537A | 2009-04-09 |
Foreign References:
| WO2009032954A1 | 2009-03-12 | |||
| WO2011032022A1 | 2011-03-17 |
Attorney, Agent or Firm:
Sonoda/Kobayashi Patent Business Corporation