Title:
Recombinant object pro-biotic bacteria for prevention of inflammatory bowel disease (IBD) and anaphylactic enteritis syndrome (IBS), and medical treatment
Document Type and Number:
Japanese Patent JP6007106
Kind Code:
B2
Abstract:
The present invention relates to the general field of therapy of Inflammatory Bowel Disease (IBD) and/or Irritable Bowel Syndrome (IBS). Thus, the invention relates to a molecule selected from the trappin-2 protein or an active fraction thereof, a member of the WAP family proteins or an active fraction thereof or a member of the Serpin family proteins or an active fraction thereof for the treatment of Irritable Bowel Syndrome (IBS). The invention also relates to a recombinant food-grade bacterium comprising a gene selected from a gene coding for the trappin-2 protein or an active fraction thereof, a gene coding for a member of the WAP family proteins or an active fraction thereof, or a gene coding for a member of the Serpin family proteins or an active fraction thereof.
Inventors:
Bergnolle, Natalie
Sarnave, Jean-Michel
Langella, Philip
Bellmudes-Humaran, Lewes
Sarnave, Jean-Michel
Langella, Philip
Bellmudes-Humaran, Lewes
Application Number:
JP2012548450A
Publication Date:
October 12, 2016
Filing Date:
January 14, 2011
Export Citation:
Assignee:
Inselm (Institut National de la Sante de la Richeche Medical)
Institute National de la Réchelche Agronomics (IANU)
INSTITUT PASTEUR
University Paris Diderot-Paris 7
Institute National de la Réchelche Agronomics (IANU)
INSTITUT PASTEUR
University Paris Diderot-Paris 7
International Classes:
A61K38/55; A61K35/74; A61K35/744; A61K35/747; A61P1/04; C12N1/21
Domestic Patent References:
| JP10127292A | ||||
| JP2007537741A | ||||
| JP2004520362A | ||||
| JP10506791A |
Foreign References:
| WO1994004697A1 |
Other References:
Eur. J. Biochem., 2004, Vol.271, No.12, pp.2370-2378
Ann. N.Y. Acad. Sci., 2006, Vol.1072, pp.176-186
Nat. Biotechnol., 2003, Vol.21, No.7, pp.785-789
SALLENAVE JEAN-MICHEL,ELAFIN IS PROTECTIVE AGAINST THE DEVELOPMENT OF COLITIS IN IBD MURINE MODELS,GASTROENTEROLOGY,2008年 4月,V134 N4,P A259
真壁和裕,細胞工学別冊 目で見る実験ノートシリーズ, バイオ実験イラストレイテッド 4苦労なしのクローニング,株式会社秀潤社,2002年 4月30日,第1版第4刷,p.197,付録 2-1-3欄
Annals of Microbiology, 2008.01, Vol.58, No.1, pp.127-131
J. Clin. Invest., 2007, Vol.117, No.3, pp.636-647
Ann. N.Y. Acad. Sci., 2006, Vol.1072, pp.176-186
Nat. Biotechnol., 2003, Vol.21, No.7, pp.785-789
SALLENAVE JEAN-MICHEL,ELAFIN IS PROTECTIVE AGAINST THE DEVELOPMENT OF COLITIS IN IBD MURINE MODELS,GASTROENTEROLOGY,2008年 4月,V134 N4,P A259
真壁和裕,細胞工学別冊 目で見る実験ノートシリーズ, バイオ実験イラストレイテッド 4苦労なしのクローニング,株式会社秀潤社,2002年 4月30日,第1版第4刷,p.197,付録 2-1-3欄
Annals of Microbiology, 2008.01, Vol.58, No.1, pp.127-131
J. Clin. Invest., 2007, Vol.117, No.3, pp.636-647
Attorney, Agent or Firm:
Ryoichi Takaoka
Nao Oda
Nao Oda