Title:
RECOMBINANT VACCINIA VIRUS
Document Type and Number:
Japanese Patent JP2021118683
Kind Code:
A
Abstract:
To provide a replication-competent recombinant oncolytic vaccinia virus (RVV), compositions comprising the RVV, and a method of using the RVV or composition for inducing oncolysis in an individual having a tumor.SOLUTION: There is provided a replication-competent recombinant RVV which comprises modifications in the viral genome relative to the corresponding wild-type virus, where the modifications comprise, in the viral genome: (1) an inserted nucleotide sequence encoding an immunostimulatory cytokine polypeptide; and (2) an inserted nucleotide sequence encoding a heterologous thymidine kinase (TK) polypeptide.SELECTED DRAWING: None
Inventors:
JOSEPH JOHN BINDER
MICHAEL DALE EISENBRAUN
DOUGLAS HANAHAN
DAVID H KIRN
CLARE LEES
PRAJIT LIMSIRICHAI
LILIANA MARURI-AVIDAL
MICHAEL DALE EISENBRAUN
DOUGLAS HANAHAN
DAVID H KIRN
CLARE LEES
PRAJIT LIMSIRICHAI
LILIANA MARURI-AVIDAL
Application Number:
JP2021001187A
Publication Date:
August 12, 2021
Filing Date:
January 07, 2021
Export Citation:
Assignee:
PFIZER
International Classes:
C12N15/26; A61K31/522; A61K35/76; A61K39/395; A61P35/00; A61P35/04; C07K14/55; C12N7/01; C12N9/12; C12N15/38; C12N15/54; C12N15/62
Attorney, Agent or Firm:
Osamu Yamamoto
Toru Miyamae
Junichi Matsuo
Reiko Izumiya
Toru Miyamae
Junichi Matsuo
Reiko Izumiya