RECOMBINANT VIRUS EXPRESSING FOREIGN DNA ENCODING FELINE CD80, FELINE CTLA-4 OR FELINE CD86 AND USE THEREOF

Japanese Patent JP2009178163

A

To provide a recombinant virus expressing foreign DNA encoding feline CD80, feline CTLA-4 or feline CD86, and to provide uses thereof.

Provided is a recombinant virus which comprises at least one foreign nucleic acid inserted within a non-essential region of the viral genome of a virus, wherein each such foreign nucleic acid encodes a protein. The protein which is encoded is selected from the groups consisting of a feline CD28 protein or an immunogenic portion thereof, a feline CD80 protein or an immunogenic portion thereof, a feline CD86 protein or an immunogenic portion thereof, or a feline CTLA-4 protein or an immunogenic portion thereof. The protein is qualified to be expressed when the recombinant virus is introduced into an appropriate host. Also provided is a recombinant virus further comprising a foreign nucleic acid encoding an immunogen derived from a pathogen. The recombinant virus includes recombinant viruses which are qualified to enhance an immune response in a feline. The recombinant virus also includes recombinant viruses which are qualified to suppress an immune response in a feline.

WINSLOW BARBARA J
COCHRAN MARK D
COLLISSON ELLEN W
HASH STEPHEN M
CHOI INSOO

JP2009091649A

August 13, 2009

April 06, 2009

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SCHERING PLOUGH LTD
TEXAS A & M UNIV SYS

A61K31/7088; C12N15/09; A61K35/76; A61K39/12; A61K39/125; A61K39/15; A61K39/215; A61K39/23; A61K39/245; A61K48/00; A61P31/12; A61P31/18; A61P35/00; A61P35/02; A61P37/04; A61P37/06; A61P43/00; C07K14/705; C12N7/00; C12N15/12; C12N15/86; C12N15/863; C12N15/869; A61K38/00

WO1996010419A2	1996-04-11
WO1991002805A2	1991-03-07

Takehiko Suzue
Toshio Shirane
Sadao Muramatsu

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