Title:
RECONSTITUTED HUMAN ANTIBODY AGAINST HUMAN INTERLEUKIN-6
Document Type and Number:
Japanese Patent JP3614183
Kind Code:
B2
Abstract:
PURPOSE: To provide the subject human antibody low in antibody nature to humans, inhibiting information transmission by IL-6, thus useful for e.g. treating diseases due to IL-6, composed of each specific complementarity determining region, L-chain variable region and human L-chain constant region.
CONSTITUTION: The objective human antibody's L-chain, composed of (A) complementarity determining region(CDR), (B) L-chain variable region(V-region) containing framework region(FR) and (C) human L-chain constant region(C- region), respectively consisting of amino acid sequences (or part thereof) of respective formulas I, II and III.
Inventors:
Masayuki Tsuchiya
Isao Sato
Yuichi Hirata
Isao Sato
Yuichi Hirata
Application Number:
JP11536794A
Publication Date:
January 26, 2005
Filing Date:
May 27, 1994
Export Citation:
Assignee:
Chugai Pharmaceutical Co., Ltd.
International Classes:
A61K39/395; A61P37/00; C12N1/21; C12N15/00; C12N15/09; C12P21/08; C12R1/19; C12R1/91; (IPC1-7): C12N15/00; C12N1/21; C12P21/08
Domestic Patent References:
| JP6147500A |
Other References:
日本免疫学会総会学術集会記録,1991,21,p.116
Proc.Natl.Acad.Sci.USA., vol.86, pp.10029-10033 (1989)
Proc.Natl.Acad.Sci.USA., vol.86, pp.10029-10033 (1989)
Attorney, Agent or Firm:
Takashi Ishida
Fukumoto product
Toshio Toda
Masaya Nishiyama
Fukumoto product
Toshio Toda
Masaya Nishiyama
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