REDIRECTION OF CELLULAR IMMUNITY BY RECEPTOR CHIMERAS

Title:

REDIRECTION OF CELLULAR IMMUNITY BY RECEPTOR CHIMERAS

Document Type and Number:

Japanese Patent JP3738024

Kind Code:

B2

Abstract:

PROBLEM TO BE SOLVED: To provide functional protein-tyrosine kinase chimeras capable of redirecting immune system function.
SOLUTION: Disclosed is a method of redirecting a cellular response in a mammal by expressing in a cell of the mammal a chimeric receptor which causes the cells to specifically recognize and destroy an infective agent, a cell infected with an infective agent, a tumor or cancerous cell, or an autoimmune-generated cell. The chimera receptor contains (a) an extracellular portion which specifically recognizes and binds a target cell or a target infective agent and (b) an intracellular portion of the protein-tyrosine kinase which is capable of signalling the cell to destroy a receptor-bound target cell or receptor-bound infective agent. Also disclosed are cells which express the chimeric receptors and DNA encoding the chimeric receptors.

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Inventors:

Seed brian
Romeo Charles
Coranus Weildemar

Application Number:

JP2004125883A

Publication Date:

January 25, 2006

Filing Date:

April 21, 2004

Export Citation:

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Assignee:

THE GENERAL HOSPITALCORPORATION

International Classes:

C12N5/10; A61K35/14; C12N15/09; A61K35/26; A61K35/54; A61K38/48; A61K38/53; A61K39/12; A61K47/42; A61P31/04; A61P31/10; A61P31/12; A61P31/18; A61P33/02; A61P37/04; A61P43/00; C07K14/705; C07K14/73; C07K19/00; C12N9/12; C12N15/00; C12N15/11; C12P21/02; A61K38/00; (IPC1-7): C12N15/09; A61K35/14; A61K35/54; A61P31/04; A61P31/10; A61P31/12; A61P31/18; A61P33/02; A61P37/04; A61P43/00; //A61K38/53; C07K14/705

Foreign References:

WO1992015322A1

Other References:

Cell,Vol.64,No.5(1991)p.1037-1046
EMBO J.,Vol.11,No.13(1992)p.4861-4868
Cold Spring Harbor Symposia Quantitative Biology,Vol.57(1992)p.117-125
Cold Spring Harbor Symposia Quantitative Biology,Vol.57(1992)p.107-116
Cell,Vol.71,No.4(1992)p.649-662
Mol.Cell.Biol.,Vol.12,No.12(1992)p.5438-5446

Attorney, Agent or Firm:

Hatsushi Shimizu

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