REDUCED CORTISOL CONJUGATE - ORTHO CLINICAL DIAGNOSTICS INC

Title:

REDUCED CORTISOL CONJUGATE

Document Type and Number:

Japanese Patent JP2011148821

Kind Code:

A

Abstract:

To provide a novel method for preparing a cortisol conjugate.

The method for preparing the cortisol conjugate includes reacting 3-cortisolcarboxymethyl oxime conjugated to bovine serum albumin (3-CMO-BSA) with sodium borohydride.

Inventors:

WARREN HAROLD C
SNYDER BRIAN A
LISA D SUPUREIGYU
SHIRLEY Y LYNN
CONTESTABLE PAUL B
HARRY L GROSS

Application Number:

JP2011090267A

Publication Date:

August 04, 2011

Filing Date:

April 14, 2011

Export Citation:

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Assignee:

ORTHO CLINICAL DIAGNOSTICS INC

International Classes:

C07J41/00; C12N15/02; C07J1/00; C07J5/00; C07J75/00; C07K14/765; C12N9/08; C12P21/08; C12Q1/28; G01N33/53; G01N33/543; G01N33/566

Domestic Patent References:

JPS5634700A	1981-04-06
JPS59104388A	1984-06-16
JPS62119457A	1987-05-30

Foreign References:

EP0003583A1

1979-08-22

Other References:

JPN6010015371; Ｅｘｐ．　Ｃｌｉｎ．　Ｅｎｄｏｃｒｉｎｌ．Ｖｏｌ．８４，　Ｎｏ．１, 1984, ｐ．６３-７０
JPN6013011722; ＳＯＮＥ，Ｈ．　ｅｔ　ａｌ: 'Ｒｅｌａｔｉｏｎｓｈｉｐｓ　ｂｅｔｗｅｅｎ　ｃｏｎｆｏｒｍａｔｉｏｎ　ｏｆ　ａｎｔｉｇｅｎ　ａｎｄ　ｓｐｅｃｉｆｉｃｉｔｙ　ｏｆ　ａｎｔｉｂｏｄｙ　ｉｎ　ｒａｄｉｏｉｍｍｕｎｏａｓｓａｙ　ｆｏｒ　ｓｔ' Ｃｈｅｍｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　ＢｕｌｌｅｔｉｎＶｏｌ．２６，　Ｎｏ．９, 1978, ｐ．２８１９-２３
JPN6013011724; ＦＡＨＭＹ，Ｄ．　ｅｔ　ａｌ: 'Ｄｅｔｅｒｍｉｎａｔｉｏｎ　ｏｆ　ｃｏｒｔｉｓｏｌ　ｉｎ　ｈｕｍａｎ　ｐｌａｓｍａ　ｂｙ　ｒａｄｉｏｉｍｍｕｎｏａｓｓａｙ　ｕｓｉｎｇ　ａｎｔｉｓｅｒｕｍｓ　ａｇａｉｎｓｔ　ｃｏｒｔｉｓｏｌ-３-ＢＳ' ＳｔｅｒｏｉｄｓＶｏｌ．２６，　Ｎｏ．３, 1975, ｐ．２６７-８０

Attorney, Agent or Firm:

Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Masaru Nakajima
Kenji Chatan

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