Title:
外来性刺激に対する細胞性応答の調整
Document Type and Number:
Japanese Patent JP3566719
Kind Code:
B2
Abstract:
The present invention relates to novel uses of xanthine derivatives, more particularly pentoxiffyline, derivatives or metabolites thereof, alone or in combination with cytochrome P450 inhibitors, such as e.g. ciprofloxacin. They may be used for treating tumors, hormone-related disorders, neurological or auto immune diseases, for treating patients undergoing bone marrow transplantation or receiving toxic agents. They are useful in modulating the effects of internal and external stimuli on cells by reversing the effects of these stimuli on the short-term secondary messenger pathways. In particular, the compounds of Formula (I), lower elevated levels of unsaturated, non-arachidonate phosphatidic acid (PA) and diacylglycerol (DAG) derived from said PA within seconds of the primary stimulus and their contact with said cells. The modulatory effect depends on the nature of the target cell and the stimulus applied.
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Inventors:
Bianco, James A
Burstain, Stuart El
Singer, Jack W
Burstain, Stuart El
Singer, Jack W
Application Number:
JP50048393A
Publication Date:
September 15, 2004
Filing Date:
May 22, 1992
Export Citation:
Assignee:
Fred Hutchinson Cancer Research Center
International Classes:
A61K31/47; A61K31/52; A61K31/522; C07D473/04; A61P35/00; (IPC1-7): A61K31/522; A61P35/00; C07D473/04
Domestic Patent References:
| JP62169788A | ||||
| JP2502542A |
Other References:
Biochemical Pharmacology,Vol.37,No.17(1988)p.3229-3236
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Tadahiko Kurita
Yasushi Kobayashi
Kiyoshi Murakami
Tadashi Masui
Tadahiko Kurita
Yasushi Kobayashi
Kiyoshi Murakami